Fig. 1

The progression of traditional Chinese medicine (TCM) syndrome in chronic hepatitis B (CHB) and gene expression analyses. a A schematic diagram illustrates the progression of TCM syndromes, each typical TCM syndrome has a different clinical manifestation. b Three-dimensional principal component analysis (PCA) shows clustering of 60 samples with TCM-syndrome progression. Each small spot represents the principal component score of the top three principle components for each sample. c Unsupervised hierarchical clustering of 60 samples based on 4252 differentially expressed genes (DEGs). Similar to (b), the healthy and LGDHS groups were clustered together, while the LDSDS were mingled with LKYDS. b, c Green, healthy; purple, LGDHS; blue, LDSDS; orange, LKYDS