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Table 2 The inhibition parameters and inhibition modes of potent ginsenoside-type hCES inhibitors

From: Inhibition of human carboxylesterases by ginsenosides: structure–activity relationships and inhibitory mechanism

Enzyme sourceTarget enzymeInhibitorIC50 (μM)Ki (μM)Inhibition modeGoodness of fit (R2)
HLMhCES1ADM1.99 ± 0.212.10Competitive0.99
DMG1.76 ± 0.282.40Competitive0.98
HLMhCES2ADM0.69 ± 0.081.22Mixed0.96
DMG1.06 ± 0.212.83Mixed0.99
PPD1.34 ± 0.110.70Mixed0.99
PPT0.86 ± 0.090.95Mixed0.99