Table 2 The inhibition parameters and inhibition modes of potent ginsenoside-type hCES inhibitors
Enzyme source | Target enzyme | Inhibitor | IC50 (μM) | Ki (μM) | Inhibition mode | Goodness of fit (R2) |
|---|---|---|---|---|---|---|
HLM | hCES1A | DM | 1.99 ± 0.21 | 2.10 | Competitive | 0.99 |
DMG | 1.76 ± 0.28 | 2.40 | Competitive | 0.98 | ||
HLM | hCES2A | DM | 0.69 ± 0.08 | 1.22 | Mixed | 0.96 |
DMG | 1.06 ± 0.21 | 2.83 | Mixed | 0.99 | ||
PPD | 1.34 ± 0.11 | 0.70 | Mixed | 0.99 | ||
PPT | 0.86 ± 0.09 | 0.95 | Mixed | 0.99 |