Fig. 7

EOFAZ attenuated HG-induced RMCs gliosis by downregulating p-CREB. mRNA level of GFAP and VEGF in RMCs were detected by qRT-PCR (a). CREB siRNA silencing efficiency (b, c). Western blot analysis was used to determine the expression of GFAP and VEGF (d, e). Data are expressed as mean ± SEM. n = 3. ^@@P < 0.01 vs. siRNA negative group. **P < 0.01 vs. control group, ^#P < 0.05, ^##P < 0.01 vs. HG group