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Fig. 7 | Chinese Medicine

Fig. 7

From: Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo

Fig. 7

Effects of SK, 4-OHT, and the combination on tumor tissues and kidney in vivo. a Ki67 expression in tumors of each group detected by immunohistochemistry. Original magnification, × 200. b The IOD of Ki67 positive cells was calculated. c H&E staining of tumor tissues of each group. Original magnification, × 200. d H&E staining of kidney of each group. Original magnification, × 200. e Tumor cells of each group underwent apoptosis (TUNEL). Original magnification, × 100. f Statistic analysis of cells underwent apoptosis. Data are the mean ± S.E.M. of three replicates. (*P < 0.05, **P < 0.01 compared with the vehicle (DMSO); #P < 0.05, ##P < 0.01 compared with the combination group)

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Chinese Medicine

ISSN: 1749-8546

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