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Fig. 3 | Chinese Medicine

Fig. 3

From: Jowiseungki decoction affects diabetic nephropathy in mice through renal injury inhibition as evidenced by network pharmacology and gut microbiota analyses

Fig. 3

Effects of JSD on the histological changes (a) and the expression of fibrosis regulators (b) in kidney tissues in DN mice. All tissues were observed under a light microscope (× 400), and representative pictures were shown. Relative levels of PKCα, TGF-β1 and α-SMA proteins were normalized to β-actin expression and determined by western blotting. Relative levels of PKCα, TGF-β1 and α-SMA mRNA were normalized to GAPDH expression and determined by reverse transcription-quantitative polymerase chain reaction analysis. Normal, normal group; Control, STZ-induced DN control group; JSD-100, 100 mg/kg JSD-administered group; JSD-500, 500 mg/kg JSD-administered group; and Met-250, 250 mg/kg metformin-administered group. Data are expressed as the mean ± S.D. (n = 7). *p < 0.05, **p < 0.01 and ***p < 0.001, the control group vs. the normal group (a)and the JSD-100, JSD-500 and Met-250 groups vs. the control group (b)

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Chinese Medicine

ISSN: 1749-8546

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