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Table 2 Rate of activation and inactivation of flavonoids on CaV channel under control conditions

From: Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis

Flavonoids

τact (ms)

τinact (ms)

n

Control

Drug

Control

Drug

Myricetin

3.1 ± 0.2

3.6 ± 0.4

116.6 ± 12.9

ND

10

29.0 ± 7.3

Quercetin

3.0 ± 0.2

6.2 ± 0.3***

94.5 ± 7.7

75.9 ± 4.3*

6

Genistein

3.1 ± 0.4

3.8 ± 0.3*

112.0 ± 7.9

133.0 ± 11.5*

7

Isorhamnetin

2.4 ± 0.2

5.4 ± 0.4**

112.8 ± 11.4

89.1 ± 8.8*

5

Luteolin

2.5 ± 0.2

2.8 ± 0.3

115.8 ± 11.1

113.6 ± 15.3

5

Apigenin

2.9 ± 0.3

2.9 ± 0.3

100.2 ± 2.6

109.6 ± 8.2

6

Chrysin

3.2 ± 0.3

3.1 ± 0.2

97.0 ± 8.6

70.8 ± 3.2**

6

Kaempferol

2.5 ± 0.3

4.6 ± 0.3***

106.7 ± 4.6

101.9 ± 7.0

6

Tamarixetin

2.3 ± 0.1

4.6 ± 0.3***

97.1 ± 7.5

98.9 ± 10.3

9

Rutin

2.3 ± 0.2

2.4 ± 0.3

122.2 ± 11.2

117.4 ± 5.4

6

(±)-Taxifolin

2.7 ± 0.2

3.0 ± 0.3

117.2 ± 10.4

111.5 ± 5.5

6

3,6,4′-Trihydroxyflavone

2.7 ± 0.2

2.9 ± 0.3

116.7 ± 17.8

114.0 ± 15.7

5

5,7,2′-Trihydroxyflavone

3.2 ± 0.4

3.3 ± 0.3

104.6 ± 9.4

103.1 ± 4.7

5

Scutellarein

2.4 ± 0.2

2.7 ± 0.2

109.7 ± 8.7

114.0 ± 7.3

6

Naringin

2.8 ± 0.1

3.3 ± 0.3

122.4 ± 16.1

109.1 ± 14.1

4

5-Hydroxyflavone

3.0 ± 0.7

2.5 ± 0.4

92.0 ± 4.8

85.5 ± 1.4

4

3,4′-Dihydroxyflavone

2.7 ± 0.2

2.9 ± 0.3

100.8 ± 9.7

98.9 ± 10.4

5

Daidzein

2.9 ± 0.4

3.1 ± 0.2

92.2 ± 9.0

110.2 ± 12.9*

5

Morin

2.7 ± 0.2

3.2 ± 0.1*

127.9 ± 10.6

158.1 ± 16.8*

5

(±)-Naringenin

2.7 ± 0.2

2.9 ± 0.3

119.6 ± 13.5

98.5 ± 8.5*

5

Resokaempferol

2.6 ± 0.3

2.7 ± 0.4

114.4 ± 14.0

110.1 ± 9.6

5

Baicalein

2.6 ± 0.2

2.9 ± 0.4

102.9 ± 9.4

99.7 ± 5.7

6

3-Methyl galangin

2.6 ± 0.4

3.0 ± 0.5

114.9 ± 5.9

82.3 ± 10.0*

4

Galangin

2.2 ± 0.2

3.1 ± 0.5

99.3 ± 7.5

89.2 ± 5.1

5

  1. ND not detectable
  2. For myricetin, both τ1act and τ2act have been reported; data = mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001