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Table 2 Rate of activation and inactivation of flavonoids on CaV channel under control conditions

From: Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis

Flavonoidsτact (ms)τinact (ms)n
ControlDrugControlDrug
Myricetin3.1 ± 0.23.6 ± 0.4116.6 ± 12.9ND10
29.0 ± 7.3
Quercetin3.0 ± 0.26.2 ± 0.3***94.5 ± 7.775.9 ± 4.3*6
Genistein3.1 ± 0.43.8 ± 0.3*112.0 ± 7.9133.0 ± 11.5*7
Isorhamnetin2.4 ± 0.25.4 ± 0.4**112.8 ± 11.489.1 ± 8.8*5
Luteolin2.5 ± 0.22.8 ± 0.3115.8 ± 11.1113.6 ± 15.35
Apigenin2.9 ± 0.32.9 ± 0.3100.2 ± 2.6109.6 ± 8.26
Chrysin3.2 ± 0.33.1 ± 0.297.0 ± 8.670.8 ± 3.2**6
Kaempferol2.5 ± 0.34.6 ± 0.3***106.7 ± 4.6101.9 ± 7.06
Tamarixetin2.3 ± 0.14.6 ± 0.3***97.1 ± 7.598.9 ± 10.39
Rutin2.3 ± 0.22.4 ± 0.3122.2 ± 11.2117.4 ± 5.46
(±)-Taxifolin2.7 ± 0.23.0 ± 0.3117.2 ± 10.4111.5 ± 5.56
3,6,4′-Trihydroxyflavone2.7 ± 0.22.9 ± 0.3116.7 ± 17.8114.0 ± 15.75
5,7,2′-Trihydroxyflavone3.2 ± 0.43.3 ± 0.3104.6 ± 9.4103.1 ± 4.75
Scutellarein2.4 ± 0.22.7 ± 0.2109.7 ± 8.7114.0 ± 7.36
Naringin2.8 ± 0.13.3 ± 0.3122.4 ± 16.1109.1 ± 14.14
5-Hydroxyflavone3.0 ± 0.72.5 ± 0.492.0 ± 4.885.5 ± 1.44
3,4′-Dihydroxyflavone2.7 ± 0.22.9 ± 0.3100.8 ± 9.798.9 ± 10.45
Daidzein2.9 ± 0.43.1 ± 0.292.2 ± 9.0110.2 ± 12.9*5
Morin2.7 ± 0.23.2 ± 0.1*127.9 ± 10.6158.1 ± 16.8*5
(±)-Naringenin2.7 ± 0.22.9 ± 0.3119.6 ± 13.598.5 ± 8.5*5
Resokaempferol2.6 ± 0.32.7 ± 0.4114.4 ± 14.0110.1 ± 9.65
Baicalein2.6 ± 0.22.9 ± 0.4102.9 ± 9.499.7 ± 5.76
3-Methyl galangin2.6 ± 0.43.0 ± 0.5114.9 ± 5.982.3 ± 10.0*4
Galangin2.2 ± 0.23.1 ± 0.599.3 ± 7.589.2 ± 5.15
  1. ND not detectable
  2. For myricetin, both τ1act and τ2act have been reported; data = mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001