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Table 4 The QSAR model with the corresponding parameters of estimates

From: Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis

Model A (for activation activity)
pIC50 = − 0.0413 k2alpha − 0.0003 Id + 0.5530 IdwAverage − 3.1819
F-stat = 3.9664 p-value < 0.001
\(r^{2}\) = 0.3182\(q^{2}\) = 0.0693\(r^{2}_{pred}\) = 0.9586
\(r^{2} \left( {se} \right)\) = 0.0933\(q^{2} \left( {se} \right)\) = 0.1090\(r^{2}_{pred} \left( {se} \right)\) = 0.0204
Model B (For inhibition activity)
pIC50 = 0.3241Most+vePotential + 0.0000MomInertiaY − 0.3600DeltaEpsilonC + 1.9116
F-stat = 1.5682 p-value < 0.001
\(r^{2}\) = 0.0845\(q^{2}\) = 0.1148\(r^{2}_{pred}\) = 0.5227
\(r^{2} \left( {se} \right)\) = 0.0804\(q^{2} \left( {se} \right)\) = 0.0887\(r^{2}_{pred} \left( {se} \right)\) = 0.0387
  1. r2, determination coefficient; q2, internal predictive ability; r2pred, external predictive ability; se, standard error; pIC50, concentration of flavonoids in logarithm scale required for 50% activation/inhibition of CaV channel activity