Table 7 The order of the flavonoids ranked by relative contribution of individual descriptors using pIC50 in model A and the order of the compounds ranked by the proportion of increase in in vivo new bone formation
No. | Name | K2alpha | Id | IdwAverage | % Increase in new bone formation in vivo |
|---|---|---|---|---|---|
1 | Scutellarein | 5.334 | 790.386 | 7.774 | – |
2 | Morin | 5.67 | 798.763 | 7.77 | – |
3 | Daidzein | 5.67 | 811.449 | 7.762 | 602% [10] |
4 | Myricetin | 5.109 | 710.672 | 7.646 | – |
5 | Apigenin | 5.109 | 717.251 | 7.641 | – |
6 | Quercetin | 5.253 | 717.251 | 7.641 | 556% [11] |
7 | (±)-Taxifolin | 12.063 | 3184.03 | 9.445 | – |
8 | 5,7,2′-Trihydroxyflavone | 5.232 | 622.413 | 7.523 | – |
9 | Genistein | 4.885 | 645.406 | 7.502 | 520% [12] |
10 | Rutin | 4.885 | 655.079 | 7.493 | – |
11 | Kaempferol | 12.328 | 3499.12 | 9.59 | – |
12 | Tamarixetin | 4.885 | 660.411 | 7.488 | – |
13 | Naringin | 4.502 | 560.369 | 7.37 | 490% [7] |
14 | Isorhamnetin | 4.661 | 561.775 | 7.371 | – |
15 | Chrysin | 4.661 | 576.201 | 7.357 | – |
16 | Galangin | 4.661 | 578.975 | 7.357 | – |
17 | Luteolin | 4.661 | 586.848 | 7.347 | – |
18 | Baicalein | 4.661 | 587.476 | 7.347 | – |
19 | Resokaempferol | 4.438 | 508.035 | 7.208 | – |
20 | 3-Methylgalangin | 4.438 | 528.263 | 7.187 | – |