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Fig. 4 | Chinese Medicine

Fig. 4

From: Fish oil protects the blood–brain barrier integrity in a mouse model of Alzheimer’s disease

Fig. 4

FO treatment inhiited the glial activation in APP/PS1 mice. a Representative images of GFAP expression in the cortex of the 5-month old APP/PS1 mice treated with FO or CO for 4 weeks and the age-matched WT mice (normal control). Higher relative optical intensity (ROI) of GFAP staining was observed in the cortex of APP/PS1 mice treated with CO compared to the WT mice, whereas FO treatment significantly suppressed astroglial activation in APP/PS1 mice compared to CO treatment (***P < 0.001; n = 5 per group). b Representative images of Iba-1 expression in the cortex of the 5-month old APP/PS1 mice treated with FO or CO for 4 weeks and the age-matched WT mice (normal control). Higher relative optical intensity (ROI) of Iba-1 staining was observed in the cortex of APP/PS1 mice treated with CO compared to the WT mice, whereas FO treatment significantly suppressed microglial activation in APP/PS1 mice compared to CO treatment (*P < 0.05; n = 5 per group). Scale bar: 75 µm

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