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Table 1 Profiles of polyunsaturated fatty acids in the hippocampus from fish oil-treated mice and the control mice with corn oil treatment (n = 3 per group)

From: Fish oil protects the blood–brain barrier integrity in a mouse model of Alzheimer’s disease

Fatty acid

Hippocampus

Corn oil-mice

Fish oil-mice

ω-6 PUFA

 LA (C18:2 ω-6)

0.91 ± 0.02

0.91 ± 0.05

 EDA (C20:2 ω-6)

0.27 ± 0.05

0.24 ± 0.03

 DGLA (C20:3 ω-6)

0.51 ± 0.03

0.47 ± 0.05

 AA (C20:4 ω-6)

13.91 ± 0.42

11.11 ± 1.02*

 DTA (C22:4 ω-6)

4.26 ± 0.17

3.99 ± 0.21

 n-6 DPA (C22:5 ω-6)

4.91 ± 0.43

1.26 ± 0.33***

 Total

28.05 ± 1.12

18.41 ± 1.16*

ω-3 PUFA

 ω-3 DPA (C22:5 ω-3)

0.15 ± 0.01

0.39 ± 0.03**

 DHA (C22:6 ω-3)

16.12 ± 1.89

27.18 ± 2.25**

 Total

16.57 ± 0.44

26.52 ± 1.21**

Total PUFA

35.75 ± 1.59

43.01 ± 1.73*

ω-6/ω-3

1.56 ± 0.06

0.68 ± 0.06**

  1. Data expressed as mol% of total fatty acids ± SEM (*P < 0.05; **P < 0.01; ***P < 0.001). AA arachidonic acid, DGLA dihomo-γ-linolenic acid, DHA docosahexaenoic acid, DPA docosapentaenoic acid, DTA docosatetraenoic acid, EDA eicosadienoic acid, LA linoleic acid, MUFA monounsaturated fatty acids (the value is given as follows: C16:1 + C18:1 + C20:1 + C22:1), SFA saturated fatty acids(the value is given as follows: C14:0 + C15:0 + C16:0 + C17:0 + C18:0 + C20:0 + C22:0 + C24:0); PUFA polyunsaturated fatty acids