Fig. 6
Interaction networks between metabolites and patient clinical parameters in Biqi and Lef group. This includes a serum of Biqi-treated patients, b serum of LEF-treated patients, c urine of Biqi-treated patients, and d urine of LEF-treated patients. Each node in round shape represents a metabolite colored based on its fold-change in responders versus non-responders at 24 weeks. Each node in diamond shape represents one clinical measurement. Each edge represents a significant correlation between the two nodes (FDR P < 0.05, residual correlation), colored by positive or negative correlations. For visualization purpose, only top 50 significant correlations between metabolites and patient clinical variables, along with any significant correlations within these metabolites are shown