Fig. 2
From: The potential insights of Traditional Chinese Medicine on treatment of COVID-19
Mechanism of LHQW in treating with COVID-19. LHQW exhibit functions on COVID-19 via “multi-component, multi-target, multi-pathway”. Firstly, major chemical constituents in LHQW could combine with SARS-CoV-2 3CL (Mpro), inhibiting the SARS-COV-2 replication. Secondly, there is an imbalance of ACE-Ang-II and ACE2-Ang-(1-7), which can lead to overwhelming pro-inflammatory cytokines with cytokine storm, LHQW could regulate balance. Thirdly, LHQW could regulate immune-related signal pathway (MAPK, NF-κB, PI3K-AKT, ect), reduce the production of pro-inflammatory cytokines