Fig. 3From: Transcriptomics- and metabolomics-based integration analyses revealed the potential pharmacological effects and functional pattern of in vivo Radix Paeoniae Alba administrationIntegrated analyses of the liver revealed that it was the site where RPA exerted a major effect. a RPA induced a number of upregulated genes (red) and downregulated genes (blue) in various vital organs (p ˂ 0.05, cutoff = 1.5). b Number of pathways enriched with DEGs in each organ, based on KEGG. c Three-dimensional PCA revealed the overall intergroup separation of the liver transcriptomes. d Volcano plot showing the upregulated genes (red) and downregulated genes (blue) in liver tissue. e Venn diagram showing the overlapping pathways enriched with DEGs from our results and previously identified targets of RPA in the TCMSP. f Venn diagram showing the overlapping pathways enriched with DEGs by GSEA. Detailed result diagrams are shown in additional filesBack to article page