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Table 1 The pharmacological effect of QBD in animal experimental study

From: Potential therapeutic effect of Qingwen Baidu Decoction against Corona Virus Disease 2019: a mini review

Disease

Animals

Experimental model

Doses (doses, route)

Pharmacological effects in QBD group

Targets

References

ALI

Male SD rats, weighting 200–250 g

LPS (2 mg/kg, intratracheal instillation)

QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.)

(1) WBC↓

(2) Lung tissue damage and inflammatory infiltration was improved

(3) W/D ratio of lung↓

IL-8↓, TNF-α↓, IL-10↑

He et al. [34]

ALI

Male SD rats, 200–250 g

LPS (2 mg/kg, intratracheal instillation)

QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.)

Inflammation score of lung histopathology in rats↓

NF-κB↓, p65↓

Wang et al. [25]

ALI

Male SD rats, weighting 200 g

LPS (5 mg/kg, intratracheal instillation)

Ethanol extraction of QBD (i.g.)

The lung volume and bleeding point of rats were significantly reduced. The color of lung tissue is dark or close to pink

NR

Ding et al. [61]

ALI

Male SD rats, 200–220 g

LPS (5 mg/kg, intratracheal instillation)

QBD dismantling (i.g.)

(1) WBC↓, PMNs↓, TNF-α↓

(2) W/D ratio of lung↓, protein concentration↓

(3) Congestion, edema and inflammatory cell infiltration of pulmonary interstitium and alveoli were decreased

NR

Zhang et al. [62]

ALI

Male Wistar rats, 220 ± 20 g

Endotoxin (3 mg/kg, i.v.)

QBD (7.5 g/kg, 15 g/kg, i.g.)

(1) Respiratory rate↓

(2) PaO2↑, PaCO2↓

(3) Pathological score↓

JAK2↓, p-JAK2↓, STAT3↓, p-STAT3↓, p38↓, p-p38↓, A-Raf↑, p-A-Raf↓

Wang et al. [63]

ALI

Male SD rats, 200–250 g

LPS (2 mg/kg, intratracheal instillation)

QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.)

Improvement in lung pathology

IL-1β↓, IL-13↑

Wang et al. [35]

ALI

Male SD rats, 200–250 g

LPS (2 mg/kg, intratracheal instillation)

QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.)

(1) WBC↓

(2) W/D ratio↓, lung coefficient↓

(3) Pathology inflammation score↓

NR

Wang et al. [36]

ALI

Male Wistar rats, 180–220 g

Endotoxin (3 mg/kg, i.v.)

QBD (7.5 g/kg, 15 g/kg, i.g.)

(1) EVLW↓, PaO2↑, PaCO2↓

(2) Pathological type II alveolar cell injury↓

(1) IL-1β↓, IL-6↓, TNF-α↓

(2) p-JAK2↓, p-STAT3↓, SOCS1↑, PIAS3↓

Wang et al. [24]

Sepsis

New Zealand rabbits, 2.19 ± 0.135 kg

Endotoxin of Escherichia coli (10 μg/kg, auricular vein injection)

QBD (873 mg/kg, i.g.)

Net increase in fever↓

TLR4↓, NF-κB↓, IL-6↓, TNF-α↓

Yi et al. [22]

Epidemic febrile disease

Male SD rats, 346 ± 26 g

Lead acetate (25 mg/kg) + LPS (15 mg/kg), caudal vein injection

QBD (15.60 g/kg, 30.29 g/kg, i.g.)

(1) Systolic pressure↑, diastolic pressure↑, mean arterial pressure↑, heart rate↑

(2) Mean time to live estimate↑, median lifetime estimate↑

NR

Yu et al. [64]

SAE

Male SD rats, 250 ± 50 g

CLP

QBD (i.g.)

(1) Neurological score↑

(2) WBC↓, NG↓

(3) TLR4 positive cells↓

TNF-α↓, IL-6↓, LTB4↓

Zheng et al. [31]

Acute peritonitis

Male SD rats, 200 g

CLP

QBD (30.8 g/kg, 40.8 g/kg, i.g.)

NR

IL-8↓, IL-10↑, TNF-α↓

Wang et al. [65]

  1. QBD Qingwen Baidu Decoction, LPS lipopolysaccharide, ALI acute lung injury, CLP cecal ligation and perforation, W/D wet to dry ratio, SAE sepsis-associated encephalopathy, NG neutrophil granulocyte, LTB4 leukotriene B4, EVLW extravascular lung water, NR not report