Disease | Animals | Experimental model | Doses (doses, route) | Pharmacological effects in QBD group | Targets | References |
---|---|---|---|---|---|---|
ALI | Male SD rats, weighting 200–250 g | LPS (2 mg/kg, intratracheal instillation) | QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) | (1) WBC↓ (2) Lung tissue damage and inflammatory infiltration was improved (3) W/D ratio of lung↓ | IL-8↓, TNF-α↓, IL-10↑ | He et al. [34] |
ALI | Male SD rats, 200–250 g | LPS (2 mg/kg, intratracheal instillation) | QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) | Inflammation score of lung histopathology in rats↓ | NF-κB↓, p65↓ | Wang et al. [25] |
ALI | Male SD rats, weighting 200Â g | LPS (5Â mg/kg, intratracheal instillation) | Ethanol extraction of QBD (i.g.) | The lung volume and bleeding point of rats were significantly reduced. The color of lung tissue is dark or close to pink | NR | Ding et al. [61] |
ALI | Male SD rats, 200–220 g | LPS (5 mg/kg, intratracheal instillation) | QBD dismantling (i.g.) | (1) WBC↓, PMNs↓, TNF-α↓ (2) W/D ratio of lung↓, protein concentration↓ (3) Congestion, edema and inflammatory cell infiltration of pulmonary interstitium and alveoli were decreased | NR | Zhang et al. [62] |
ALI | Male Wistar rats, 220 ± 20 g | Endotoxin (3 mg/kg, i.v.) | QBD (7.5 g/kg, 15 g/kg, i.g.) | (1) Respiratory rate↓ (2) PaO2↑, PaCO2↓ (3) Pathological score↓ | JAK2↓, p-JAK2↓, STAT3↓, p-STAT3↓, p38↓, p-p38↓, A-Raf↑, p-A-Raf↓ | Wang et al. [63] |
ALI | Male SD rats, 200–250 g | LPS (2 mg/kg, intratracheal instillation) | QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) | Improvement in lung pathology | IL-1β↓, IL-13↑ | Wang et al. [35] |
ALI | Male SD rats, 200–250 g | LPS (2 mg/kg, intratracheal instillation) | QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) | (1) WBC↓ (2) W/D ratio↓, lung coefficient↓ (3) Pathology inflammation score↓ | NR | Wang et al. [36] |
ALI | Male Wistar rats, 180–220 g | Endotoxin (3 mg/kg, i.v.) | QBD (7.5 g/kg, 15 g/kg, i.g.) | (1) EVLW↓, PaO2↑, PaCO2↓ (2) Pathological type II alveolar cell injury↓ | (1) IL-1β↓, IL-6↓, TNF-α↓ (2) p-JAK2↓, p-STAT3↓, SOCS1↑, PIAS3↓ | Wang et al. [24] |
Sepsis | New Zealand rabbits, 2.19 ± 0.135 kg | Endotoxin of Escherichia coli (10 μg/kg, auricular vein injection) | QBD (873 mg/kg, i.g.) | Net increase in fever↓ | TLR4↓, NF-κB↓, IL-6↓, TNF-α↓ | Yi et al. [22] |
Epidemic febrile disease | Male SD rats, 346 ± 26 g | Lead acetate (25 mg/kg) + LPS (15 mg/kg), caudal vein injection | QBD (15.60 g/kg, 30.29 g/kg, i.g.) | (1) Systolic pressure↑, diastolic pressure↑, mean arterial pressure↑, heart rate↑ (2) Mean time to live estimate↑, median lifetime estimate↑ | NR | Yu et al. [64] |
SAE | Male SD rats, 250 ± 50 g | CLP | QBD (i.g.) | (1) Neurological score↑ (2) WBC↓, NG↓ (3) TLR4 positive cells↓ | TNF-α↓, IL-6↓, LTB4↓ | Zheng et al. [31] |
Acute peritonitis | Male SD rats, 200 g | CLP | QBD (30.8 g/kg, 40.8 g/kg, i.g.) | NR | IL-8↓, IL-10↑, TNF-α↓ | Wang et al. [65] |