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Table 1 The pharmacological effect of QBD in animal experimental study

From: Potential therapeutic effect of Qingwen Baidu Decoction against Corona Virus Disease 2019: a mini review

Disease Animals Experimental model Doses (doses, route) Pharmacological effects in QBD group Targets References
ALI Male SD rats, weighting 200–250 g LPS (2 mg/kg, intratracheal instillation) QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) (1) WBC↓
(2) Lung tissue damage and inflammatory infiltration was improved
(3) W/D ratio of lung↓
IL-8↓, TNF-α↓, IL-10↑ He et al. [34]
ALI Male SD rats, 200–250 g LPS (2 mg/kg, intratracheal instillation) QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) Inflammation score of lung histopathology in rats↓ NF-κB↓, p65↓ Wang et al. [25]
ALI Male SD rats, weighting 200 g LPS (5 mg/kg, intratracheal instillation) Ethanol extraction of QBD (i.g.) The lung volume and bleeding point of rats were significantly reduced. The color of lung tissue is dark or close to pink NR Ding et al. [61]
ALI Male SD rats, 200–220 g LPS (5 mg/kg, intratracheal instillation) QBD dismantling (i.g.) (1) WBC↓, PMNs↓, TNF-α↓
(2) W/D ratio of lung↓, protein concentration↓
(3) Congestion, edema and inflammatory cell infiltration of pulmonary interstitium and alveoli were decreased
NR Zhang et al. [62]
ALI Male Wistar rats, 220 ± 20 g Endotoxin (3 mg/kg, i.v.) QBD (7.5 g/kg, 15 g/kg, i.g.) (1) Respiratory rate↓
(2) PaO2↑, PaCO2↓
(3) Pathological score↓
JAK2↓, p-JAK2↓, STAT3↓, p-STAT3↓, p38↓, p-p38↓, A-Raf↑, p-A-Raf↓ Wang et al. [63]
ALI Male SD rats, 200–250 g LPS (2 mg/kg, intratracheal instillation) QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) Improvement in lung pathology IL-1β↓, IL-13↑ Wang et al. [35]
ALI Male SD rats, 200–250 g LPS (2 mg/kg, intratracheal instillation) QBD (7.395 g/kg, 14.79 g/kg, 29.58 g/kg, i.g.) (1) WBC↓
(2) W/D ratio↓, lung coefficient↓
(3) Pathology inflammation score↓
NR Wang et al. [36]
ALI Male Wistar rats, 180–220 g Endotoxin (3 mg/kg, i.v.) QBD (7.5 g/kg, 15 g/kg, i.g.) (1) EVLW↓, PaO2↑, PaCO2↓
(2) Pathological type II alveolar cell injury↓
(1) IL-1β↓, IL-6↓, TNF-α↓
(2) p-JAK2↓, p-STAT3↓, SOCS1↑, PIAS3↓
Wang et al. [24]
Sepsis New Zealand rabbits, 2.19 ± 0.135 kg Endotoxin of Escherichia coli (10 μg/kg, auricular vein injection) QBD (873 mg/kg, i.g.) Net increase in fever↓ TLR4↓, NF-κB↓, IL-6↓, TNF-α↓ Yi et al. [22]
Epidemic febrile disease Male SD rats, 346 ± 26 g Lead acetate (25 mg/kg) + LPS (15 mg/kg), caudal vein injection QBD (15.60 g/kg, 30.29 g/kg, i.g.) (1) Systolic pressure↑, diastolic pressure↑, mean arterial pressure↑, heart rate↑
(2) Mean time to live estimate↑, median lifetime estimate↑
NR Yu et al. [64]
SAE Male SD rats, 250 ± 50 g CLP QBD (i.g.) (1) Neurological score↑
(2) WBC↓, NG↓
(3) TLR4 positive cells↓
TNF-α↓, IL-6↓, LTB4↓ Zheng et al. [31]
Acute peritonitis Male SD rats, 200 g CLP QBD (30.8 g/kg, 40.8 g/kg, i.g.) NR IL-8↓, IL-10↑, TNF-α↓ Wang et al. [65]
  1. QBD Qingwen Baidu Decoction, LPS lipopolysaccharide, ALI acute lung injury, CLP cecal ligation and perforation, W/D wet to dry ratio, SAE sepsis-associated encephalopathy, NG neutrophil granulocyte, LTB4 leukotriene B4, EVLW extravascular lung water, NR not report