Table 4 Quality consistency evaluation with biological evaluation and chemical–biological integration evaluation technology

Scutellariae Radix

HPLC–PDA/QTOF–MS, antioxidant and anti-inflammatory bioactivities assays

Multivariate statistical analysis-based bridging, SA, HCA

[117]

Radix Isatidis

Neuraminidase activity assay

Parallel lines of qualitative effect

[121]

XST capsules

Antiplatelet aggregation

Parallel line assay

[122]

Xiaojin Pills

Antiplatelet aggregation

Simplified probit principle

[149]

Qingkailing injection

Bioactivity fingerprints

SA, One-way anova, CA

[123]

Lianhua Qingwen capsules

Microcalorimetry, growth metabolic thermogram

Regression analysis

[124]

Cardiotonic Pills

Gene chip, qrt-PCR, UPLC fingerprint

SA

[125]

Shuanghuanglian freeze-dried powder for injection

HPLC-ELSD fingerprints, Microcalorimetry

SA

[134]

Huangqin Tang, PHY906

LC/MS fingerprinting, bioresponse fingerprinting, in vivo validation, 18× Luciferase report cell lines

Phytomics Similarity Index (PSI)

[135, 136]

YIQING tablets

HPLC–DAD fingerprint, HPLC–DPPH assay

PCA, average linear quantitative fingerprint, multiwavelength total fusion profiling

[137]

Powdered Poppy capsules

HPLC fingerprint, Antioxidant Activities

Averagely linear-quantified fingerprint method, OPLS

[138]

Coptidis Rhizoma

HPLC fingerprint

Effective constituent equivalence, PLS-DA

[140]

Coptidis Rhizoma

HPLC, antibacterial zone

PCA, IC₅₀

[141]

Huangqi injection solution

¹H NMR Fingerprint

SA, relative content determination

[145]

Bufo bufo gargarizans Cantor

LC–MS/MS, Cytotoxicity assay in vitro, metabolomic

Markers-NMBT

[146]

Salvia miltiorrhiza Bunge

Micellar electrokinetic capillary chromatography fingerprint, antioxidant activity

SQFM, PCA

[147]

Tianma Toutong tablets

HPLC five-wavelength fingerprints, antioxidant activity

SQFM, PCA, PLS model

[148]

Lianqiao Baidu Pills

HPLC five-wavelength fingerprints, antioxidant activity

Limited-ratio quantified fingerprint method, PCA, PLS model

[150]

Sanhuang tablets

Capillary electrophoresis fingerprints, antioxidant activity

PLS model

[151]

Yinqiaojiedu tablets

Capillary electrophoresis fingerprints, antioxidant activity

PCA, PLS model

[152]

Sophora flavescens

Capillary electrophoresis fingerprints, antioxidant activity

Linear quantitative profiling method, PLS model

[153]

Weibizhi tablets

Micellar electrokinetic chromatography fingerprinting, antioxidant activity

Simple quantified ratio fingerprint method, PLS model

[154]

Fufang Danshen Pills

Micellar electrokinetic chromatography fingerprint, Antioxidant activity

SQFM, PLS model

[155]

Ixeris sonchifolia

Microemulsion electrokinetic chromatography fingerprints, antioxidant activity

PCA, OPLS

[156]

Ixeris sonchifolia

HPLC fingerprint, antioxidant activity

SQFM, SVM, PCA, PLS, OPLS

[157]

Sophora flower-bud, Sophora flower

HPLC-Q-TOF MS, antioxidant and hyaluronidase inhibitory activities

PLSR, BP-ANN, PCA

[158]

Matricaria chamomilla L.

HPLC fingerprint, antioxidant activity

PCA, HCA

[159]

Compound Danshen tablets

HPLC multiwavelength fusion fingerprints, antioxidant activity

SQFM, SA,

[160]

Lianqiao Baidu Pills

Micellar electrokinetic capillary chromatography fingerprint, antioxidant activity

Limited-ratio quantified fingerprint method, PCA, HCA, PLS model

[161]

Isatidis Folium

HPLC fingerprint, antioxidant activity

Equal weight quantified ratio fingerprint method, PLSR

[162]

Compound Liquorice tablets

HPLC multi-wavelength fusion fingerprint, antioxidant activity

Averagely linear quantified fingerprint method, HCA, PCA, PLS model

[163]

Zhenju Jiangya tablets

HPLC multi-wavelength fusion fingerprint, antioxidant activity

SQFM, PCA, PLS model

[164]