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Table 3 Relevant researches of NCTD against invasion and metastasis for multiple cell lines in different cancer models

From: Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities

Cancers Cell lines Basic mechanisms Pathways Accompanying roles Experiment References
Gallbladder cancer GBC-SD Upregulating TIMP-2 and MMP-2/TIMP-2 ratio, downregulating MMP-2    In vitro [142]
Colorectal cancer CT26 Downregulating MMP-9 and gelatinase; inhibiting the DNA-binding activity of Sp1 Inhibiting Sp1 transcriptional activity   In vitro [77]
Downregulating αvβ6, MMP-3, MMP-9, N-cadherin, vimentin, p-ERK, p-Ets1; up-regulating E-cadherin Inhibiting EMT by blocking αvβ6-ERK-Ets1 signaling pathway    [78]
CT26 Down-expressing MMP-2, -9 and Desmoglein, N-cadherin, α- and β-catenin; reducing pulmonary metastasis.   Prolonging mice survival In vitro
In vivo
Inhibiting migration; enhancing the anticancer effects of gefitinib and cisplatin Not altering p-EGFR With gefitinib and cisplatin synergistic effect In vitro [54]
Interfering the YAP-mediated cell progression and metastasis; inhibiting EMT, motile, invasion via enhancing E-cadherin and decreasing fibronectin/vimentin; repressing YAP and its downstream CYR61, CTGF Repressing YAP signal pathway    [80]
A549 Suppressing migration Inhibiting p-Akt, NF-κB With trichostatin A, celecoxib, lovastatin, synergistic effect In vitro
Ex vivo
Breast cancer MCF-7 Inhibiting adhesion and migration, repressing cell adhesion to platelets via downregulating α2 integrin Activating protein kinase C pathway via PP2A inhibition. via protein kinase C pathway-dependent, downregulation of α2 integrin   In vitro [63]
Hepatocellular cancer Huh7
Downregulating MMP-9, u-PA, p-ERK1/2, NF-kB, FAK; upregulating PAI-1 and TIMP-1 Inhibiting the phosphorylation of ERK1/2 and NF-kB signaling pathway   In vitro [170]
SMMC-7721, MHCC-97H Suppressing cell motility and invasiveness; up-regulating FAM46C; suppressing TGF-β/Smad signaling, EMT Up-regulating FAM46C via brocking EMT process and TGF-β/Smad signaling    [9]
Inhibiting IL-6-induced EMT and cell invasiveness, and JAK/STAT3/TWIST signaling Inhibiting IL-6-induced EMT via JAK2/STAT3/TWIST signaling    [81]
Osteosarcoma MG63
Inhibiting the expression of MMP-2 and MMP-9    In vitro
In vivo
Giant cell tumor of bone (GCTB)   Inhibiting the EMT process Modulating the miR-30a/MTDH/AKT cell signaling pathway   In vitro [169]