Skip to main content
Fig. 5 | Chinese Medicine

Fig. 5

From: Identification of drug targets and potential molecular mechanisms for Wantong Jingu Tablet extract in treatment of rheumatoid arthritis: bioinformatics analysis of fibroblast-like synoviocytes

Fig. 5

Identification of hub genes by the combined use of DESeq2 with WGCNA. Venn diagram of the DEGs among different groups, showing 1196 common DEGs (a). Time series cluster analysis of 1196 DEGs, confirming 16 model profiles (b). 331 DEGs from the two model profiles (profile#0 and profile#15), bearing a positive or negative correlationship with the treatment time (c). Clustering of the 331 DEGs by WGCNA, and identification of two co-expression modules: turquoise module and blue module (d). Dotplot of the KEGG pathway analysis for the turquoise and blue modules (e). Co-expression network of DEGs in the significantly enriched pathways was constructed by Cytoscape software and the node degrees were analyzed (f). PPI network of DEGs in the significantly enriched pathways, and the node degrees in PPI relationship (g). n = 3 per group

Back to article page

Chinese Medicine

ISSN: 1749-8546

Contact us