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Table 1 Analysis of differences in expression levels of inflammasome related molecules in HNSCC by Oncomine Database

From: RalB degradation by dihydroartemisinin induces autophagy and IFI16/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma

 

Head–neck carcinoma vs. normal

Head–neck carcinoma vs. buccal mucosa

Head–neck carcinoma vs. normal

TCGA head–neck database (n = 290)

Ginos head–neck database (n = 54)

Cromer head–neck database (n = 38)

Fold change

P-value

t-test

Fold change

P-value

t-test

Fold change

P-value

t-test

IFI16

1.048

1.71E−11

6.889

3.115

9.22E−15

13.011

1.435

0.17

1.117

AIM2

1.048

1.71E−11

6.882

5.674

6.51E−14

11.201

2.028

0.001

3.912

NLRP1

− 1.035

1

− 4.674

1.674

0.037

1.878

1.089

0.428

0.192

NLRP3

1.053

3.73E−12

7.133

1.4551

0.035

1.879

1.555

0.192

0.976

NLRC4

1.033

2.02E−08

5.633

      

NLRC5

1.001

0.443

0.144

      

NLRP6

− 1.064

1

− 7.355

      

NLRP12

− 1.017

0.994

− 2.53

      

NOD1

1.08

1.64E−19

9.62

2.322

1.12E−04

5.034

   

NOD2

− 1.005

0.747

− 0.664

− 1.72

1

− 3.866

   

CASP1

− 1.079

1

− 6.227

1.445

4.26E−04

3.548

1.325

0.215

0.869

IL1B

1.028

2.40E−06

4.661

2.801

1.77E−08

6.605

4.908

0.002

5.574

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Chinese Medicine

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