Group | Dose (mg/kg) | LVSP (mmHg) | LVEDP (mmHg) | +dp/dtmax (mmHg/s) | −dp/dtmax (mmHg/s) | SBP (mmHg) | DBP (mmHg) | MAP (mmHg) |
---|---|---|---|---|---|---|---|---|
Sham | – | 121.52 ± 11.58 | 12.80 ± 4.36 | 5486.62 ± 1274.77 | − 4514.28 ± 1206.89 | 127.43 ± 13.73 | 101.40 ± 12.91 | 110.08 ± 12.24 |
MI | – | 92.20 ± 9.14** | 24.62 ± 11.53** | 2879.57 ± 699** | − 2602.23 ± 709.79** | 94.94 ± 14.45** | 68.32 ± 9.91** | 77.19 ± 10.94** |
Captopril | 10 | 117.70 ± 10.11## | 11.07 ± 5.43## | 5492.85 ± 1056.12## | − 4690.98 ± 407.66## | 112.86 ± 14.92#* | 83.65 ± 14.24#** | 93.38 ± 13.06##** |
Digoxin | 0.032 | 107.94 ± 10.11##** | 12.82 ± 4.35## | 4334.41 ± 805.68##* | − 3688.32 ± 679.12## | 117.25 ± 14.03## | 89.02 ± 14.92## | 98.43 ± 13.30## |
Liguzinediol | 5 | 112.95 ± 7.67## | 14.50 ± 5.08# | 4716.70 ± 761.77## | − 3902.99 ± 593.81## | 117.29 ± 13.67## | 86.93 ± 12.69##* | 97.05 ± 12.52##* |
10 | 116.26 ± 12.91## | 13.77 ± 4.13# | 4870.57 ± 839.12## | − 4052.40 ± 914.03## | 119.43 ± 13.13## | 89.17 ± 11.07##* | 99.26 ± 11.34## | |
20 | 119.48 ± 7.28## | 13.47 ± 5.15# | 5205.27 ± 968.84## | − 4408.84 ± 704.99## | 123.03 ± 14.78## | 93.47 ± 11.70## | 103.32 ± 12.46## |