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Fig. 6 | Chinese Medicine

Fig. 6

From: Cryptotanshinone attenuates the stemness of non-small cell lung cancer cells via promoting TAZ translocation from nuclear to cytoplasm

Fig. 6

CT reduces the stemness of NSCLC CSCs dependent on TAZ expression. a, b TAZ mRNA and protein levels were examined in NSCLC spheroids with CT treatment plus TAZ overexpression or not. ce The expression of stemness markers (Oct4 and nanog) was detected in the spheroids depicted in (a). f, g The capacity of spheroid formation was evaluated in the spheroids described in (a) via measuring spheroid size and number. h ALDH1 activity was determined in the spheroids described in (a). Data were presented as the mean ± sd, **P < 0.01 vs. control (empty lentivirus for Len-TAZ and scramble shRNA lentivirus for Len-TAZ-kd), CT (20 μM) group contained the empty lentivirus for Len-TAZ

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