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Fig. 3 | Chinese Medicine

Fig. 3

From: Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions

Fig. 3

The effects of several circulating compounds towards eight expressed CYP isozymes and three recombinant UGT enzymes. a Kang-Ai injection, b oxymatrine, c astragaloside IV, d ginsenosides Rg1, and e ginsenoside Rc; The probe substrates were incubated at 37 °C in the absence (control, 0 μM) and presence of tested mixture and compounds (Kang-Ai injection and samples that Kang-Ai injection was diluted 10 times; 1, 10, and 100 μM for oxymatrine; 0.1, 1, 10 and 100 μM for astragalosides and ginsenosides). Data represent the mean ± standard deviation of triplicate, (* compared with those of control, * p < 0.05)

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Chinese Medicine

ISSN: 1749-8546

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