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Fig. 5 | Chinese Medicine

Fig. 5

From: Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions

Fig. 5

The Dixon plots for the inhibition effects of circulating saponins against recombinant CYP and UGT isozymes. a Inhibition effect of astragaloside IV against tolbutamide-4-hydroxylation for CYP2C9; b Inhibition effect of ginsenoside Rg1 towards β-estradiol-3-O-glucuronidation for UGT1A1; c Inhibition effect of ginsenoside Re against paclitaxel-6-hydroxylation for CYP2C8; d Inhibition effect of ginsenoside Rd towards bupropion-hydroxylation for CYP2B6; e Inhibition effect of ginsenoside Rd against nifedipine-oxidation for CYP3A4; f Inhibition effect of ginsenoside Rc towards propofol-O-glucuronidation for UGT1A9; g Inhibition effect of ginsenoside Rb1 against tolbutamide-4-hydroxylation for CYP2C9; All data represent the mean ± SD of triplicate determinations

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Chinese Medicine

ISSN: 1749-8546

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