The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions

Ali, Youmna; Shams, Tahiatul; Wang, Ke; Cheng, Zhengqi; Li, Yue; Shu, Wenying; Bao, Xiaofeng; Zhu, Ling; Murray, Michael; Zhou, Fanfan

doi:10.1186/s13020-020-00351-9

Chinese Medicine

Table 1 Potential drug-herb/food interactions involving OATPs

From: The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions

Herbal or dietary product	Chemicals identified in extracts	OATP	Substrate	Effect on transporter	apparent IC₅₀	K_i	Cell model	Refs.
Bofutsushosan extract		2B1	ES	Inhibition	14 μg/ml		HEK 293	[71]
Rhei Rhizoma	EGCG ECG (+)-catechin EC EGC anthraquinones emodin	2B1	ES	Inhibition	3.7 μg/ml		HEK 293	[71]
Perillae herba extract	Scutellarin	2B1	ES	Inhibition	8.2 μg/ml		HEK 293	[71]
Scuterallia Radix	Baicalin	2B1	ES	Inhibition	11 μg/ml		HEK 293	[67]
Glyryrrhizae Radix Licorice	Glycyrrhizic acid	2B1 1B1	ES ES	Inhibition Inhibition	18 μg/ml 14.6 μM		HEK 293 HEK 293	[71] [72]
Moutan cortex	β-PGG	2B1	ES	Inhibition	31 μg/ml		HEK 293	[73]
Paeoniae Radix	β-PGG	2B1	ES	Inhibition	0.15 mg/ml		HEK 293	[71]
Tribuli Fructus Saussurea Radix Curcumae Rhizoma Tomato Buckwheat	Rutin	2B1	ES	Activation			HEK 293	[71]
	Rutin	1B1	DHEAS	Activation			HeLa	[74]
Chinese skullcap	Baicalin Baicalin Baicalein	2B1	ES	Inhibition	5.6 ± 3.2 μM		HEK 293	[67]
Chinese skullcap	Baicalin Baicalin Baicalein	1B3	CCK-8	Inhibition	13.7 ± 3.6 μM 7.7 ± 2.4 μM		HEK 293	[67]
Horny goat weed	Icariin	2B1 1B1	ES	Inhibition	6.4 ± 1.9 μM 21.9 ± 2.0 μM		HEK 293	[27] [63]
Horny goat weed	Icariin	1B3	CCK-8	Inhibition	3.0 ± 1.3 μM		HEK 293	[27] [63]
Radix Astragali	Astragaloside	1B1	ES	Inhibition	25.5 μM		HEK 293	[72]
Panax ginseng	Ginsenoside Rc	1B1	ES	Inhibition	18.5 μM		HEK 293	[72]
Pyrola incarnate Fisch	2-O-galloyl hyperin	1B1	ES	Inhibition	19 μM		HEK 293	[72]
Herba Epimedii	Epimedin C	1B1	ES	Inhibition	23.5 μM		HEK 293	[72]
Milk thistle	Silymarin	1B1	Estradiol-17β-glucuronide	Inhibition	1.3 μM		HEK 293	[75]
		1B3	Estradiol-17β-glucuronide	Inhibition	2.2 μM		HEK 293	[75]
		2B1	ES	Inhibition	0.3 μM		MDCKII	[75]
Breviscapine	Scutellarin	1B1	ES	Inhibition	28.4 μM		HEK 293	[72]
Breviscapine	Scutellarin	2B1	ES	Inhibition	2 μM		HEK 293	[76]
Grapefruit juice	Naringenin	2B1	ES	Inhibitor	16 μM		HEK 293	[71]
	Naringenin	1A2	Fexofenadine	Inhibitor	3.6 μM		HeLa	[77]
	hesperidin	2B1		Inhibitor
	hesperidin	1A2	Fexofenadine	Inhibitor	2.7 μM		HeLa	[77]
Apple juice	Phlorizin	1B1	DHEAS	Inhibition			HeLa	[74]
	Quercetin	1A2	BSP	Inhibition		22 μM	HEK 293	[78]
		2B1	BSP	Inhibition		8.7 μM	HEK 293	[78]
		1B1	ES	Inhibition	20.4 μM		HEK 293	[72]
	Kaempferol	1A2	BSP	Inhibition		25.5 μM	HEK 293	[78]
	Kaempferol	2B1	BSP	Inhibition		15.1 μM	HEK 293	[78]
Black tea	Theaflavin	2B1	ES	Inhibition		8.2 μM	HEK 293	[79]
Green tea	ECG EGCG ECG EGCG ECG EGCG ECG EGCG	1B1	ES	Inhibition	58.6 μM 7.8 μM		CHO	[65]
		2B1	ES	Inhibition	35.9 μM 101 μM		CHO	[65]
		1A2	ES	Inhibition	10.2 μM 54.8 μM	10.4 μM 18.8 μM	HEK 293	[65]
		1B3	ES	Activation		34.1 μM 13.2 μM	CHO	[65]
Pomegranate	Ursolic acid	2B1	ES	Inhibition	11.0 ± 5.0 μM		HEK 293	[64]
		1B1	ES	Inhibition	22.4 μM		HEK 293	[72]
		1B3	Fluorescein-methotrexate	Inhibition	365.1 nM		HEK 293	[68]
	Gallic acid	1B3	CCK-8	Inhibition	1.60 ± 0.60 μM		HEK 293	[64]
	Oleanolic acid	1B1	ES	Inhibition	28.5 μM		HEK 293	[72]
Red clover in soy Peanuts Chickpea	Biochanin A	1B1	DHEAS	Inhibition	11.3 ± 3.2 μM		HeLa	[74]
White mulberry	Mulberrin	2B1	ES	Inhibition	1.8 μM		HEK 293	[76]
Apple peel Olives	Betulinic acid	1B3	Fluorescein derivatives	Inhibition	368.2 nM		HEK 293	[68]

ECG epicatechin gallate, EGCG epigallocatechin gallate, EC epicatechin, EGC epicatechin-3-gallate, β-PGG 1,2,3,4,6-penta-O-galloyl-β-d-glucose
ES estrone sulphate, DHEAS dehydroepiandrosterone sulphate, BSP bromosulphophthalein, CCK-8 cholecystokinin

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ISSN: 1749-8546

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