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Table 2 Potential targets of CDPF against COVID-19

From: Potential mechanism prediction of Cold-Damp Plague Formula against COVID-19 via network pharmacology analysis and molecular docking

Protein name

Gene symbol

Uniprot ID

Prostaglandin G/H synthase 1

PTGS1

P23219

Prostaglandin G/H synthase 2

PTGS2

P35354

Mothers against decapentaplegic homolog 3

SMAD3

P84022

Heme oxygenase 1

HMOX1

P09601

Granulocyte–macrophage colony-stimulating factor

CSF2

P04141

Nitric oxide synthase, inducible

NOS2

P35228

Peroxisome proliferator activated receptor gamma

PPARG

P37231

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

PIK3CG

P48736

Dipeptidyl peptidase IV

DPP4

P27487

Nitric-oxide synthase, endothelial

NOS3

P29474

Transcription factor p65

RELA

Q04206

Apoptosis regulator Bcl-2

BCL2

P10415

Apoptosis regulator BAX

BAX

Q07812

Tumor necrosis factor

TNF

P01375

Caspase-3

CASP3

P42574

Mitogen-activated protein kinase 8

MAPK8

P45983

Signal transducer and activator of transcription 1-alpha/beta

STAT1

P42224

Intercellular adhesion molecule 1

ICAM1

P05362

Transthyretin

TTR

P02766

Coagulation factor Xa

F10

P00742

Epidermal growth factor receptor

EGFR

P00533

Bcl-2-like protein 1

BCL2L1

Q07817

Proto-oncogene c-Fos

FOS

P01100

Mitogen-activated protein kinase 1

MAPK1

P28482

Interleukin-10

IL10

P22301

Retinoblastoma-associated protein

RB1

P06400

Interleukin-6

IL6

P05231

Cellular tumor antigen p53

TP53

P04637

Caspase-8

CASP8

Q14790

Superoxide dismutase [Cu–Zn]

SOD1

P00441

Protein kinase C alpha type

PRKCA

P17252

Interleukin-1 beta

IL1B

P01584

C–C motif chemokine 2

CCL2

P13500

Interleukin-8

CXCL8

P10145

Protein kinase C beta type

PRKCB

P05771

Heat shock protein beta-1

HSPB1

P04792

Interleukin-2

IL2

P60568

Plasminogen activator inhibitor 1

SERPINE1

P05121

Interferon gamma

IFNG

P01579

Interleukin-1 alpha

IL1A

P01583

Poly [ADP-ribose] polymerase 1

PARP1

P09874

C-X-C motif chemokine 11

CXCL11

O14625

C-X-C motif chemokine 2

CXCL2

P19875

C-X-C motif chemokine 10

CXCL10

P02778

CD40 ligand

CD40LG

P29965

Phosphatidylinositol 3-kinase regulatory subunit alpha

PIK3R1

P27986

Induced myeloid leukemia cell differentiation protein Mcl-1

MCL1

Q07820

Interleukin-4

IL4

P05112

Cyclic AMP-responsive element-binding protein 1

CREB1

P16220

Glucose-6-phosphate 1-dehydrogenase

G6PD

P11413

Catalase

CAT

P04040

Cytosolic phospholipase A2

PLA2G4A

P47712

Protein kinase C epsilon type

PRKCE

Q02156

Mitogen-activated protein kinase 3

MAPK3

P27361

Calmodulin-1

CALM1

P0DP23

T-cell surface glycoprotein CD4

CD4

P01730

Mitogen-activated protein kinase 14

MAPK14

Q16539

Nuclear factor NF-kappa-B p105 subunit

NFKB1

P19838

Angiotensin-converting enzyme

ACE

P12821

Cyclin-dependent kinase 4

CDK4

P11802

CD81 antigen

CD81

P60033

Eukaryotic translation initiation factor 2 subunit 1

EIF2S1

P05198

Growth factor receptor-bound protein 2

GRB2

P62993

Apolipoprotein E

APOE

P02649

C–C chemokine receptor type 3

CCR3

P51677

Angiotensin-converting enzyme 2

ACE2

Q9BYF1

Aminopeptidase N

ANPEP

P15144

Serine/threonine-protein kinase/endoribonuclease IRE1

ERN1

O75460

Cyclic AMP-dependent transcription factor ATF-2

ATF2

P15336

Cathepsin B

CTSB

P07858

Peptidyl-prolyl cis–trans isomerase A

PPIA

P62937