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Table 2 Potential targets of CDPF against COVID-19

From: Potential mechanism prediction of Cold-Damp Plague Formula against COVID-19 via network pharmacology analysis and molecular docking

Protein name Gene symbol Uniprot ID
Prostaglandin G/H synthase 1 PTGS1 P23219
Prostaglandin G/H synthase 2 PTGS2 P35354
Mothers against decapentaplegic homolog 3 SMAD3 P84022
Heme oxygenase 1 HMOX1 P09601
Granulocyte–macrophage colony-stimulating factor CSF2 P04141
Nitric oxide synthase, inducible NOS2 P35228
Peroxisome proliferator activated receptor gamma PPARG P37231
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform PIK3CG P48736
Dipeptidyl peptidase IV DPP4 P27487
Nitric-oxide synthase, endothelial NOS3 P29474
Transcription factor p65 RELA Q04206
Apoptosis regulator Bcl-2 BCL2 P10415
Apoptosis regulator BAX BAX Q07812
Tumor necrosis factor TNF P01375
Caspase-3 CASP3 P42574
Mitogen-activated protein kinase 8 MAPK8 P45983
Signal transducer and activator of transcription 1-alpha/beta STAT1 P42224
Intercellular adhesion molecule 1 ICAM1 P05362
Transthyretin TTR P02766
Coagulation factor Xa F10 P00742
Epidermal growth factor receptor EGFR P00533
Bcl-2-like protein 1 BCL2L1 Q07817
Proto-oncogene c-Fos FOS P01100
Mitogen-activated protein kinase 1 MAPK1 P28482
Interleukin-10 IL10 P22301
Retinoblastoma-associated protein RB1 P06400
Interleukin-6 IL6 P05231
Cellular tumor antigen p53 TP53 P04637
Caspase-8 CASP8 Q14790
Superoxide dismutase [Cu–Zn] SOD1 P00441
Protein kinase C alpha type PRKCA P17252
Interleukin-1 beta IL1B P01584
C–C motif chemokine 2 CCL2 P13500
Interleukin-8 CXCL8 P10145
Protein kinase C beta type PRKCB P05771
Heat shock protein beta-1 HSPB1 P04792
Interleukin-2 IL2 P60568
Plasminogen activator inhibitor 1 SERPINE1 P05121
Interferon gamma IFNG P01579
Interleukin-1 alpha IL1A P01583
Poly [ADP-ribose] polymerase 1 PARP1 P09874
C-X-C motif chemokine 11 CXCL11 O14625
C-X-C motif chemokine 2 CXCL2 P19875
C-X-C motif chemokine 10 CXCL10 P02778
CD40 ligand CD40LG P29965
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 P27986
Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1 Q07820
Interleukin-4 IL4 P05112
Cyclic AMP-responsive element-binding protein 1 CREB1 P16220
Glucose-6-phosphate 1-dehydrogenase G6PD P11413
Catalase CAT P04040
Cytosolic phospholipase A2 PLA2G4A P47712
Protein kinase C epsilon type PRKCE Q02156
Mitogen-activated protein kinase 3 MAPK3 P27361
Calmodulin-1 CALM1 P0DP23
T-cell surface glycoprotein CD4 CD4 P01730
Mitogen-activated protein kinase 14 MAPK14 Q16539
Nuclear factor NF-kappa-B p105 subunit NFKB1 P19838
Angiotensin-converting enzyme ACE P12821
Cyclin-dependent kinase 4 CDK4 P11802
CD81 antigen CD81 P60033
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 P05198
Growth factor receptor-bound protein 2 GRB2 P62993
Apolipoprotein E APOE P02649
C–C chemokine receptor type 3 CCR3 P51677
Angiotensin-converting enzyme 2 ACE2 Q9BYF1
Aminopeptidase N ANPEP P15144
Serine/threonine-protein kinase/endoribonuclease IRE1 ERN1 O75460
Cyclic AMP-dependent transcription factor ATF-2 ATF2 P15336
Cathepsin B CTSB P07858
Peptidyl-prolyl cis–trans isomerase A PPIA P62937