Fig. 1

a The mice were randomly divided into CON, MOD, HYF, ESC and SCHY groups. b From D0 to D15, mice were administered intraperitoneal injection of 160 mg/kg VCD, while mice in the CON group were injected with sesame oil. From D1 to the end, the HYYKF was gavaged in the HYF and SCHY group, while equal volume of saline were gavaged in CON, MOD and ESC group. The mouse ESCs suspension was injected once through the tail vein 10 days at D25 in ESC and SCHY group. c The underlying mechanism through TGF-β signaling pathway. d The morphology and pluripotency of the ESCs. Brightfield.The morphology of the ESCs under the light microscope. GFP. Most clones were GFP positive, indicating the ESCs were pluripotent and undifferentiated