Fig. 5
SGE alleviated IL-1β-induced proliferation and migration in the human synovial SW982 cell line. SW982 cells were seeded in 96-well (1 × 104 cells/well) or 24-well (1 × 105 cells/well) plates and allowed to grow for 24 h. A scratch wound was built in each group with a 10 μL pipette tip in the 24-well plate. Cells were co-treated with the indicated concentrations of SGE for 24 h in the absence or presence of IL-1β (20 ng/mL). The cell viability was determined by MTT assay (a, b). The images of the scratch wound were obtained with a microscope (d) and scratch wound changes were analyzed (c) after determining the wound size with Image J software (#P < 0.05, ###P < 0.001 vs. Ctrl group; **P < 0.01, ***P < 0.01 vs. IL-1β group; n = 3)