Parameter | Mean ± SD |
---|
AUC0-∞ (ng·hr/mL) | 1218.319 ± 326.042 |
AUC0-t (ng·hr/mL) | 1186.935 ± 323.500 |
Cmax (ng/mL) | 407.888 ± 85.732 |
Tmax (hr) | 1.750 ± 1.255 |
t1/2 (hr) | 8.283 ± 0.538 |
MRT0-∞ (hr) | 6.897 ± 0.954 |
MRT0-t (hr) | 5.433 ± 0.581 |
Clast (ng/mL) | 2.621 ± 0.665 |
- AUC0-t, the area under the curve from 0 time to 48 h; AUC0-∞, the area under the curve from 0 time to infinity; Cmax, the maximum drug concentration in plasma; t1/2, half-life; Tmax, time taken to reach maximum drug concentration in plasma; MRT0-∞ (hr), mean residence time from 0 to infinity last measured concentration; MRT0- t (hr), mean residence time from 0 time to 48 h; Clast, last measured concentration