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Table 2 Pharmacokinetic parameters of decursin after oral administration of RAGE

From: Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation

Parameter

Mean ± SD

AUC0-∞ (ng·hr/mL)

1218.319 ± 326.042

AUC0-t (ng·hr/mL)

1186.935 ± 323.500

Cmax (ng/mL)

407.888 ± 85.732

Tmax (hr)

1.750 ± 1.255

t1/2 (hr)

8.283 ± 0.538

MRT0-∞ (hr)

6.897 ± 0.954

MRT0-t (hr)

5.433 ± 0.581

Clast (ng/mL)

2.621 ± 0.665

  1. AUC0-t, the area under the curve from 0 time to 48 h; AUC0-∞, the area under the curve from 0 time to infinity; Cmax, the maximum drug concentration in plasma; t1/2, half-life; Tmax, time taken to reach maximum drug concentration in plasma; MRT0-∞ (hr), mean residence time from 0 to infinity last measured concentration; MRT0- t (hr), mean residence time from 0 time to 48 h; Clast, last measured concentration