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Table 1 The components of SB

From: Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

No. Name Molecular formula Weight Plant part Ref.
1 Baicalein (5,6,7-Trihydroxyflavone) C15H10O5 270 Root
Hairy Root
[37]
2 Methoxybaicalein (5,6-Dihydroxy-7-methoxyflavone) C16H12O5 284 Root [117]
3 Scutellarein (5,6,7,4′-Tetrahydroxyflavone) C15H10O6 286 Root [39]
4 5,6,7-Trihydroxy-4′-methoxyflavone C16H12O6 300 Aerial part [38]
5 Oroxylin A (5,7-Dihydroxy-6-methoxyflavone) C16H12O5 284 Root [37]
6 Tenaxin II (5,7,2′-Trihydroxy-6-methoxyflavone) C16H12O6 300 Root [38]
7 5,7,4′-Trihydroxy-6-methoxyflavone C16H12O6 300 Aerial part [38]
8 5,7-Dihydroxy-6,8-dimethoxyflavone C17H14O6 314 Root [38]
9 5,7,2′-Trihydroxy-6,8-dimethoxyflavone C17H14O7 330 Root [38]
10 5,8-Dihydroxy-6,7-dimethoxyflavone C17H14O6 314 Root [38]
11 5,8,2′-Trihydroxy-6,7-dimethoxyflavone C17H14O7 330 Root [38]
12 Tenaxin I (5,2′-Dihydroxy-6,7,8-trimethoxyflavdne) C18H16O7 344 Root [38]
13 5,2′,5′-Trihydroxy-6,7,8-trimethoxyflavone C18H16O8 360 Root [38]
14 Skullcapflavone II (5,6′-Dihydroxy-6,7,8,2′-tetramethoxyflavone) C19H18O8 374 Root
Hairy Root
[37]
15 5,4′-Dihydroxy-6,7,3′,5′-tetramethoxyflavone C19H18O8 374 Aerial part [38]
16 5,2′-Dihydroxy-6,7,8,3′-tetramethoxyflavone C19H18O8 374 Hairy Root [38]
17 Chrysin (5,7-Dihydroxyflavone) C15H10O4 254 Root
Aerial part
[37]
18 Norwogonin (5,7,8-Trihydroxyflavone) C15H10O5 270 Root [38]
19 lsoscutellarein (5,7,8,4′-Tetrahydroxyflavone) C15H10O6 286 Aerial part [38]
20 Apigenin (5,7,4′-Trihydroxyflavone) C15H10O5 270 Root
Aerial part
[39]
21 4′-Hydroxywogonin (5,7 4′-Trihydroxy-8-methoxyflavone) C16H12O6 300 Root [38]
22 2′-Hydroxychrysin (5,7,2′-Trihydroxyflavone) C15H10O5 270 Root [38]
23 5,7,2′,3′-Tetrahydroxyflavone C15H10O6 286 Root [38]
24 6-Hydroxyluteolin C15H10O7 292 Whole plant [39]
25 Salvigenin C18H16O7 344 Root [38]
27 Luteolin C15H10O6 286 Whole plant [39]
26 5,7,2′,5′-Tetrahydroxyflavone C15H10O6 286 Root [38]
28 5,7,2′,6′-Tetrahydroxyflavone C15H10O6 286 Root [38]
29 5,7,6′-Trihydroxy-2′-methoxyflavone C16H12O6 300 Root [38]
30 5,7-Dihydroxy-6,8,2′,3′-tertramethoxyflavone C19H18O7 358 Root [38]
31 Wogonin (5,7-Dihydroxy-8-methoxyflavone) C16H12O5 284 Root
Aerial part
Hairy Root
[37]
32 3,5,4′-Trihydroxy-6,7,8-trimethoxyflavone C18H16O8 360 Whole plant [39]
33 Scutevulin (5,7,2′-Trihydroxy-8-methoxyflavone) C16H12O6 300 Root [38]
34 5,7,6′-Trihydroxy-8,2′-dimethoxyflavone C17H14O7 330 Root [37]
35 Viscidulin III (5,7,3′,6′-Tetrahydroxy-8,2′-dimethoxyflavone) C17H14O8 346 Root [38]
36 5,7,2′-Trihydroxy-6′-methoxyflavone C16H12O6 300 Root [38]
37 5,7-Dihydroxy-8,2′,3′,6′-tetramethoxyflavone C19H18O8 374 Root [38]
38 7-Methoxychrysin (5-Hydroxy-7-methoxyflavone) C16H12O4 268 Aerial part [38]
39 5,8-Dihydroxy-7-methoxyflavone C16H12O5 284 Root [38]
40 Genkwanin (5.,4′-Dihydroxy-7-methoxyflavone) C16H12O5 284 Aerial part [38]
41 5,8,2′-Trihydroxy-7-methoxyflavone C16H12O6 300 Root [38]
42 7-O-Methylwogonin (5-Hydroxy-7,8-dimethoxyflavone) C17H14O5 298 Root [38]
43 5,7,4′-Trihydroxy-8-methoxyflavone C17H12O6 312 Root [38]
44 Skullcapflavone I (5,2′-Dihydroxy-7,8-dimethoxyflavone) C17H14O6 314 Root
Hairy Root
[38]
45 Viscidulin II (5,2′,6′-Trihydroxy-7,8-dimethoxyflavone) C17H14O7 330 Root [38]
46 Rivularin (5,6′-Dihydroxy-7,8,2′-trimethoxyflavone) C18H16O7 344 Root
Hairy Root
[38]
47 6′-Hydroxy-5,6,7,8,2′-pentamethoxyflavone C20H20O8 388 Root [38]
48 6,б′-Dihydroxy-5,7,8,2′-tetramethoxyflavone C19H18O8 374 Root [38]
49 5,7,3′4′,5′-Pentamethoxyflavone C20H20O7 372 Aerial part [38]
50 Viscidulin I (5,7,2′,6′-Tetrahydroxyflavonol) C15H10O7 302 Root [37]
51 5,7,6′-Trihydroxy-2′-methoxyflavonol C16H12O7 316 Root [38]
52 Baicalein 6-O-glucuronide C21H18O11 446 Whole plant [39]
53 6-Hydroxyluteolin 7-O-glucoronide C21H18O13 478 Whole plant [39]
54 Luteolin 7-O-glucuronide C21H18O12 462 Whole plant [39]
55 Apigenin 7,4′-di-O-rhamnoside C21H20O8 400 Whole plant [39]
56 8-Methoxy-5-O-glucosideflavone C22H20O10 444 Root [38]
57 Apigenin 7-O-β-D-glucoside C21H20O10 432 Aerial part [39]
58 Baicalein 7-O-β-D-glucoside C21H20O10 432 Root
Aerial part
[37]
59 Oroxylin A 7-O-β-D-glucoside C21H20O100 446 Aerial part
Root
[37]
60 Apigenin 6-C-glucosyl-8-C-arabinoside C26H28O14 564 Whole plant [39]
61 5,6′-Dihydroxy-7,8-dimethoxyflavone 2′-O-β-D-glucoside C23H24O12 492 Root
Hairy Root
[37]
62 5,6′-Dihydroxy-6,7,8-trimethoxyflavone 2′-O-β-D-glucoside C24H26O13 522 Root [38]
63 5,6′-Dihydroxy-6,7-dimethoxyflavone 2′-O-β-D-glucoside C23H24O12 492 Root
Hairy Root
[38]
[38]
64 5,7,6′-Trihydroxyflavone 2′-O-β-D-glucoside C21H20O11 448 Hairy Root [37]
65 Viscidulin III 6′-O-β-D-glucoside C23H24O13 508 Root
Hairy Root
[37]
66 Wogonin 5-O-β-D-glucoside C22H22O10 446 Root [37]
67 3,5,7,6′-Tetrahydroxyflavone 2′-O-β-D-glucoside C21H20O12 464 Root [38]
68 Kaempferol 3-O-β-D-glucoside C21H20O11 448 Aerial part [38]
69 Chrysin 7-O-β-d-glucuronide C21H18O10 430 Root
Aerial part
[37]
70 Baicalin (5,6-Dihydroxyflavone 7-O-β-D-glucuronide) C21H18O11 446 Root
Aerial part
Hairy Root
[37]
71 5,2′-Dihydroxy-6-methoxyflavone 7-O-β-D-glucuronide C22H20O12 476 Root [37]
72 Wogonoside (Wogonin 7-O-β-D-glucuronide) C22H20O11 460 Root
Hairy Root
[37]
73 Oroxyloside (Oroxylin A 7-O-β-D-glucuronide) C22H20O11 460 Root [37]
74 Norwogonin 7-O-β-D-glucuronide (5,8-dihydroxyflavone 7-O-β-D-glucuronide) C21H18O11 446 Root [37]
75 Isoscutellarein 8-O-β-D-glucuronide C24H24O12 504 Leaf [38]
76 5-Hydroxy-7,8,6′-trimethoxyflavone 2′-O-β-D-glucuronide C24H24O13 520 Hairy Root [38]
77 Scutellarin C21H18O12 462 Root [37]
78 Apigenin 7-O-β-D-glucuronide C21H18O11 446 Aerial part [39]
79 Patuletin 7-O-β-D-glucuronide (3,5,3′,4′-Tetrahydroxy-6-methoxyflavone 7-O-β-D-glucuronide) C22H20O14 508 Root [38]
80 Chrysin 8-C-β-D-glucoside C21H20O9 416 Root [37]
81 Chrysin 6-C-β-d-glucoside C21H20O9 416 Root [38]
82 Chrysin 6-C-β-D-glucoside-8-C-α-l-arabinopyranoside C26H28O13 548 Root
Hairy Root
[37]
83 Chrysin 6-C-α-l-arabinopyranoside-8-C-β-D-glucoside C26H28O13 548 Root
Hairy Root
[37]
84 Chrysin 6-C-β-l-arabinopyranoside-8-C-β-D-glucoside C26H28O13 548 Root [39]
85 Chrysin 6-C-β-D-glucoside-8-C-β-l-arabinopyranoside C26H28O13 548 Root [39]
86 Chrysin 6-C-β-arabinofuranoside-8-C-β-D-glucoside C26H28O13 548 Root [39]
87 Chrysin 6-C-β-d-glucoside-8-C-β-arabinofuranoside C26H28O13 548 Root [39]
88 Chrysin 3-C-α-arabinopyranoside-8-C-β-D-glucoside C26H28O13 548 Root [39]
89 Apigenin 6-C-α-l-arabinopyranoside-8-C-β-D-glucoside(isoschaftoside) C26H28O14 564 Aerial part [39]
90 Viscidulin III-2′-O-β-D-glucopyranoside C23H22O14 522 Root [38]
91 Quercetin 3-glucuronide C21H18O13 478 Whole plant [39]
92 Naringenin C15H12O5 272 Whole plant [39]
93 Pinocembrin C15H12O4 256 Whole plant [39]
94 lsocarthamidin ((2S)-5,7,8,4′-Tetrahydroxyflavanone) C15H12O6 288 Leaf
Root
[39]
95 Carthamidin (2S)-5,6,7,4′-Tetrahydroxyflavanone) C15H12O6 288 Leaf
Root
[39]
96 (2S)-5,7,4′-Trihydroxy-6-methoxyflavanone C16H14O6 302 Root [38]
97 (+)-Eriodictyol ((2S)-5,7,3′,4′-Tetrahydroxyflavanone) C15H12O6 288 Root [38]
98 (2S)-5,4′-Dihydroxy-7-methoxyflavanone C16H14O5 286 Aerial part [38]
99 Dihydrooroxylin A ((2S)-5,7-Dihydroxy-6-methoxyflavanone) C16H14O5 286 Root [38]
100 (2S)-7-Hydroxy-5-methoxyflavanone C16H14O4 270 Root [38]
101 (2S)-5,7,2′,5′-Tetrahydroxyflavanone C15H12O6 288 Root [38]
102 (2S)-5,7,2′,6′-Tetrahydroxyflavanone C15H12O6 288 Root [37]
103 (2S)-7,2′,6′-Trihydroxy-5-methoxyflavanone C16H14O6 302 Root [38]
104 (2R,3R)-3,5,7,2′,6′-Pentahydroxyflavanone C15H12O7 304 Root [37]
106 Naringenin 7-O-glucoronide C21H20O11 448 Whole plant [39]
107 Pinocembrin 7-O-glucoronide C21H20O10 432 Whole plant [39]
108 (2S) -5,7,2′,5′-Tetrahydroxyflavanone-7-O-β-D-glucopyranoside C21H22O10 434 Root [38]
109 (2S)-5,7-Dihydroxy-6-methoxyflavanone-7-O-β-D-glucopyranoside C22H22O10 446 Root [38]
110 (2S)-5-Hydroxy-6-methoxyflavanone 7-O-β-D-glucoside C22H24O10 448 Root [38]
111 (2S)-5,7,6′-Trihydroxyflavanone 2′-O-β-D-glucoside C21H22O11 450 Root [37]
112 Dihydrobaicalin ((2S)-5,6-Dihydroxyflavanone 7-O-β-D-glucuronide) C21H20O11 448 Root [38]
113 (2S)-5-Hydroxy-6-methoxyflavanone 7-O-β-D-glucuronide C22H22O11 462 Root [37]
114 (2S)-5,6,3′,4′-Tetrahydroxyflavanone 7-O-β-D-glucuronide C21H20O13 480 Aerial part [38]
115 Isocarthamidin-7-O-β-D-glucuronide ((2S)-5,8,4′-Trihydroxyflavanone 7-O-β-D-glucuronide) C21H20O12 464 Aerial part [39]
116 Carthamidin 7-O-β-D-glucuronide (Dihydroscutellarein 7-O-β-D-glucuronide, Scutellarin B) C21H20O12 464 Aerial part [39]
117 (2S)-5,8,3′,4′-Tetrahydroxyflavanone 7-O-β-D-glucuronide C21H20O13 480 Aerial part [38]
118 4′,5,7-Trihydroxy-6-methoxyflavanone C16H15O5 287 Root [38]
119 2′,6′,5,7-Tetrahydroxyflavanone C15H13O5 273 Root [38]
120 Sinapoyl hexoside C27H22O10 386 Whole plan [39]
121 Verbascoside C29H36O15 624 Whole plant [39]
122 7-O-Acetylloganic acid C28H26O10 402 Whole plant [39]
123 N1,N5,N10-Tri-p-(E,E,E)-coumaroylspermidine C33H33O6N3 567 Whole plant [39]
124 Benzyl alcohol C7H8O 108 Root [36]
125 4′-(β-D-glucopyranosyloxy)-3,3′,5,5′-tetramethoxy-9,9′-epoxylignane-4, 7′-diol C30H45O13 613 Root [36]
126 4′-(β-D-glucopyranosyloxy)-3,3′,5′-trimethoxy-9,9′-epoxylignane-4, 7′-diol C29H43O12 583 Root [36]
127 4′-(β-D-glucopyranosyloxy)-3,3-dimethoxy-9,9′-epoxylignane-4,7′-diol C28H41O11 553 Root [36]
128 Lutein C40H55O2 567 Root [36]
129 β-Carotene C40H56 536 Root [36]
130 2,6,2′,4′-Tetrahydroxy-6′-methoxychalcone C16H14O6 302 Root [38]
131 8,8″-Bibaicalein C30H18O10 538 Root [38]
132 5,6,8-Trimethoxy-3′,4′-methylenedioxyflavone 7-O-β-D-glucoside C26H28O12 532 Root [38]
133 3,5,8-Trimethoxy-3′,4′-methylenedioxyflavone 7-O-β-D-glucoside C26H28O12 532 Root [38]
134 Delphinidin 3-O-(6-O-malonyl)-β-d-glucoside-5-O-β-D-glucoside C30H33O20 713 Flower [38]
135 Salidroside (4-Hydroxy-β-phenylethyl-β-D-glucoside) C14H20O7 300 Hairy Root [38]
136 Darendoside B C21H32O12 476 Root [38]
137 Martynoside (2-(3-Hydroxy-4-methoxyphenyl) ethyl-1-O-α-l-rhamnosyl(1 → 3)-β-D-(4-feruloyl)-glucoside) C31H40O15 652 Hairy Root
Root
[38]
138 Acteoside C29H36O15 624 Hairy Root
Root
[37]
139 Isomartynoside C31H40O15 652 Root [38]
140 Leucosceptoside A C30H38O15 638 Hairy Root
Root
[38]
141 Cistanoside D C31H40O15 652 Root [37]
142 Darendoside A C19H28O11 432 Root [38]
143 Stigmasterol C29H48O 412 Root [38]
144 β-Sitosterol C29H50O 414 Root [36]
145 Daucosterin C35H60O6 576 Root [38]
146 Scutebaicalin (6α,7β-dibenzoyloxy-8β-hydroxy-neo-cleroda-4(18),13-dien-15,16-olide) C34H38O7 558 Aerial part [38]
147 Pellitorine C14H25NO 223 Root [38]
148 (E)-4-[(2-methylpropyl) amino]-4-oxo-2-butenoic acid C8H13NO3 171 Root [38]
149 Dihydropiperlonguminine C16H21NO3 275 Root [38]
150 Futoamide C18H23NO3 301 Root [38]
151 Piperlonguminine C16H19NO3 273 Root [38]
152 Benzoic acid C7H6O2 122 Root [38]
153 Phenyl acetic acid C8H8O2 136 Root [38]
154 Syringaldehyde C9H10O4 182 Root [38]
155 4-O-β-D-glucosyl-trans-p-coumaric acid C15H18O8 326 Root [38]
156 Ferulic acid methyl ester C11H12O4 208 Root [38]
157 4-O-β-D-glucosyl-cis-p-coumaric acid C15H18O8 326 Root [38]
158 Vanillin C8H8O3 152 Root [38]
159 (+)-Crotepoxide C18H18O8 362 Root [38]
160 (+)-Syringaresinol-O-β-D-glucoside C28H36O13 580 Root [38]