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Table 2 Alkaloids with analgesic activity isolated from Chinese herbal medicines

From: Effects of alkaloids on peripheral neuropathic pain: a review

Alkaloids Sub-groups Example CAS Molecular formula Sources Latin name References
Quinolizidine alkaloids Matrine 519-02-8 C15H24N2O Baicihua Sophora davidii [156]
Kudouzi Sophora alopecuroides [156,157,158]
Kushen Sophora flavescens [156, 159]
Shandougen Sophora subprostrata [156]
Oxymatrine 16837-52-8 C15H24N2O2 Baicihua Sophora davidii [156]
Kudouzi Sophora alopecuroides [157, 158]
Kushen Sophora flavescens [159]
Shashenhuai Sophora moorcroftiana [156]
Shandougen Sophora subprostrata [156]
Isoquinoline alkaloids Berberine 2086-83-1 C20H18NO4+ Baiqucai Chelidonium majus [160]
Baiyaozi Stephania cepharantha [160]
Banruitangsongcao Thalictrum petaloideum [160]
Huangbai Phellodendron amurense [161]
Huanglian Coptis chinensis [162]
Maweilian Thalictrum foliolosum [160]
Yanguocao Thalictrum minus [160]
Yanhusuo Corydalis yanhusuo [163]
Levo-Tetrahydropalmatine 10097-84-4 C21H25NO4 Yanhusuo Corydalis yanhusuo [156]
Xiatianwu Corydalis decumbens [156]
Juhuahuanglian Corydalis pallida [156]
Chibanyanhusuo Corydalis remota [164]
Sinomenine 115-53-7 C19H23NO4 Bianfugegen Menispermum dauricum [160]
Qingfengteng Sinomenium acutum [160, 165]
Dehydrocorydaline 30045-16-0 C22H24NO4+ Yanhusuo Corydalis yanhusuo [160]
Levo-Corydalmine 30413-84-4 C20H23NO4 Yanhusuo Corydalis yanhusuo [160]
Palmatine 3486–67-7 C21H22NO4+ Banruitangsongcao Thalictrum petaloideum [164]
Yanguocao Thalictrum minus [164]
Huangbai Phellodendron amurense [164]
Huanglian Coptis chinensis [164]
Haisongzi Pinus koraiensis [164]
Maweilian Thalictrum foliolosum [164]
Xiatianwu Corydalis decumbens [164]
Huanglian Coptis teetoides [164]
Yanhusuo Corydalis yanhusuo [164]
Alishanshidagonglao Mahonia oiwakensis [166]
Qingniudan Tinospora sagittata [167]
Indole alkaloids Evodiamine 518-17-2 C19H17N3O Wuzhuyu Evodia rutaecarpa [168]
Dehydrocrenatidine 65236-62-6 C15H14N2O2 Kumu Picrasma quassioides [101]
Brucine 57-24-9 C23H26N2O4 Maqianzi Strychnos nux-vomica [169]
Koumine 1358-76-5 C20H22N2O Gouwen Gelsemium elegans [170]
Gelsenicine 82354-38-9 C19H22N2O3 Gouwen Gelsemium elegans [170]
Gelsemine 509-15-9 C20H22N2O2 Gouwen Gelsemium elegans [137, 170]
Isorhynchophylline 6859-01-4 C22H28N2O4 Gouteng Uncaria rhynchophylla [171]
Diterpenoid alkaloids Isotalatizidine 7633-68-3 C23H37NO5 Chuanwu Aconitum carmichaeli [172]
Bulleyaconitine A 107668-79-1 C35H49NO9 Caowu Aconitum bulleyanum [173]
Bullatine A 1354-84-3 C21H31NO2 Xueshangyizhihao Aconitum brachypodum [45]
guan-fu base A 1394-48-5 C24H31NO6 Guanbaifu Aconitum coreanum [174]
Lappaconitine 32854-75-4 C32H44N2O8 Ganwanwutou Aconitum finetianum [156]
Gaowutou Aconitum sinomontanum [156]
Niubian Aconitum barbatum [156]