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Fig. 1 | Chinese Medicine

Fig. 1

From: Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice

Fig. 1

Palmitate induced insulin resistance in C2C12 myotubes. After the cells were starved for 4 h and incubated with 0.2 or 0.4 mM palmitate for 24 h. The glucose uptake (a) was determined with 2-NBDG kits, and the phosphorylation of IRS-1 at Ser 307 (b), Ser 612 (c), and AKT at Thr 308 (d) and Ser 473 (e) was detected with western blot. Data are mean ± SD (n = 3) from three independent experiments. @@p < 0.01 vs. control (no insulin stimulation), **p < 0.01 vs. 100 nM insulin alone

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