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Table 1 The parameters of “Drug-Like Soft” rule

From: Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology

Property Range Property Range
MW 100–600 Rings  ≤ 6
logP − 3 to 6 Max size system ring  ≤ 18
HBA  ≤ 12 Carbons 3–35
HBD  ≤ 7 Hetero atoms 1–15
tPSA  ≤ 180 H/C ratio 0.1–1
Rotatable bonds  ≤ 11 Charges  ≤ 4
Rigid bonds  ≤ 30 Total charge − 4 to 4