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Table 1 The parameters of “Drug-Like Soft” rule

From: Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology

Property

Range

Property

Range

MW

100–600

Rings

 ≤ 6

logP

− 3 to 6

Max size system ring

 ≤ 18

HBA

 ≤ 12

Carbons

3–35

HBD

 ≤ 7

Hetero atoms

1–15

tPSA

 ≤ 180

H/C ratio

0.1–1

Rotatable bonds

 ≤ 11

Charges

 ≤ 4

Rigid bonds

 ≤ 30

Total charge

− 4 to 4