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Table 4 The top 10 hub genes ranked with different algorithms

From: Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology

Category Rank method in CytoHubba
MCC MNC Degree EPC Closeness radiality
Gene symbol top 10 AKT1 AKT1 AKT1 AKT1 AKT1 AKT1
EGFR EGFR EGFR EGFR EGFR EGFR
PTGS2 ESR1 ESR1 PTGS2 PTGS2 PTGS2
MAPK14 PTGS2 PTGS2 ESR1 ESR1 ESR1
ESR1 MMP9 MMP9 MAPK14 MMP9 MMP9
KDR MAPK14 MAPK14 MMP9 MAPK14 MAPK14
MMP9 PIK3CA PIK3CA KDR KDR KDR
MMP2 KDR KDR PIK3CA PIK3CA APP
MMP3 MPO MPO APP APP PIK3CA
APP PIK3R1 PIK3R1 IGF1R IGF1R IGF1R