Table 4 The top 10 hub genes ranked with different algorithms
| Category | Rank method in CytoHubba | |||||
|---|---|---|---|---|---|---|
| MCC | MNC | Degree | EPC | Closeness | radiality | |
| Gene symbol top 10 | AKT1 | AKT1 | AKT1 | AKT1 | AKT1 | AKT1 |
| EGFR | EGFR | EGFR | EGFR | EGFR | EGFR | |
| PTGS2 | ESR1 | ESR1 | PTGS2 | PTGS2 | PTGS2 | |
| MAPK14 | PTGS2 | PTGS2 | ESR1 | ESR1 | ESR1 | |
| ESR1 | MMP9 | MMP9 | MAPK14 | MMP9 | MMP9 | |
| KDR | MAPK14 | MAPK14 | MMP9 | MAPK14 | MAPK14 | |
| MMP9 | PIK3CA | PIK3CA | KDR | KDR | KDR | |
| MMP2 | KDR | KDR | PIK3CA | PIK3CA | APP | |
| MMP3 | MPO | MPO | APP | APP | PIK3CA | |
| APP | PIK3R1 | PIK3R1 | IGF1R | IGF1R | IGF1R | |