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Table 5 The top 10 signaling pathways with related genes

From: Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology

Term Pathway Genes
hsa04923 Regulation of lipolysis in adipocytes PIK3CG, AKT1, PTGS2, PIK3CB, PTGS1, PIK3CA, ADORA1, INSR, PIK3R1
hsa04917 Prolactin signaling pathway PIK3CG, AKT1, PIK3CB, MAPK14, GSK3B, ESR1, PIK3CA, STAT1, PIK3R1
hsa04668 TNF signaling pathway PIK3CG, AKT1, PTGS2, PIK3CB, MAPK14, MMP9, PIK3CA, MMP14, MMP3, PIK3R1
hsa04370 VEGF signaling pathway PIK3CG, AKT1, PTGS2, PIK3CB, MAPK14, PIK3CA, PIK3R1, KDR
hsa04068 FoxO signaling pathway PIK3CG, AKT1, EGFR, IGF1R, PIK3CB, MAPK14, PIK3CA, INSR, PIK3R1, CDK2
hsa04915 Estrogen signaling pathway PIK3CG, AKT1, EGFR, PIK3CB, MMP9, ESR1, PIK3CA, MMP2, PIK3R1
hsa00591 Linoleic acid metabolism CYP3A4, ALOX15, CYP2C19, CYP2C9, PLA2G1B, CYP1A2
hsa04015 Rap1 signaling pathway PIK3CG, AKT1, EGFR, IGF1R, ADORA2A, PIK3CB, MAPK14, PIK3CA, INSR, PIK3R1, KDR
hsa00590 Arachidonic acid metabolism ALOX15, CYP2C19, PTGS2, CYP2C9, PTGS1, PLA2G1B, ALOX12
hsa04380 Osteoclast differentiation PIK3CG, AKT1, PIK3CB, MAPK14, LCK, PIK3CA, STAT1, PIK3R1, SYK