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Fig. 1 | Chinese Medicine

Fig. 1

From: Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway

Fig. 1

The regulation of TFEB and ALP. mTORC1 holds TFEB in a phosphorylated state. Phosphorylated TFEB binds to the 14-3-3 protein, which sequesters it in the cytoplasm. However, mTORC1 dependent/independent pathways that activate TFEB can dephosphorylate TFEB, and dephosphorylated TFEB translocates to the nucleus and binds to the CLEAR sequence, leading to upregulation of the autophagy and lysosomal genes. PI3K class III phosphatidylinositol 3-kinase, AMPK AMP-activated protein kinase, ULK UN51-like Ser/Thr kinases complex, mTOR Mammalian (or Mechanistic) target of rapamycin, mTORC mTOR complex, CLEAR coordinated lysosomal expression and regulation, TFEB transcription factor EB, MCOLN1 calcium channel mucolipin 1, CN calcineurin

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