Metabolomics coupled with integrated approaches reveal the therapeutic effects of higenamine combined with [6]-gingerol on doxorubicin-induced chronic heart failure in rats

Table 2 Effects of HG/[6]-GR on hemodynamic indices in rats

Group	LVSP (mmHg)	LVEDP (mmHg)	+ dp/dt_max (mmHg/s)	-dp/dt_max (mmHg/s)
C	140.56 ± 12.75	− 12.97 ± 2.85	7506.87 ± 668.49	− 5330.51 ± 884.92
DOX	51.57 ± 8.38^**	10.54 ± 1.83^**	2313.95 ± 416.24^**	− 1386.08 ± 172.61^**
DH	132.04 ± 10.48^##	− 7.40 ± 0.89^##	8579.56 ± 873.29^##	− 6757.02 ± 601.40^##
HG	112.30 ± 10.91^##	− 1.47 ± 2.59^##	9034.06 ± 426.66^##	− 6778.09 ± 291.51^##
[6]-GR	100.91 ± 12.02^##	7.34 ± 0.86^##	5029.14 ± 256.68^##	− 3729.03 ± 104.06^##
HG/[6]-GR	125.25 ± 7.92^##abb	− 4.07 ± 0.93^##abb	10,263.24 ± 1056.67^##aabb	− 8428.85 ± 399.13^##aabb

ISSN: 1749-8546