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Table 2 The chemical properties and pharmacological activities of novel compounds

From: Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review

Compound name Formula Plant part Analytical method Type of compound Bioactivity References
Cablinosides A C23H34O10 Leaves HR-ESI-MS; UV; IR; NMR; HPLC; CD Glycosides α-glucosidase inhibitory activity (IC50 = 278.4 ± 2.8 µM) [35]
Cablinosides B C23H34O10 Leaves HR-ESI-MS; UV; IR; NMR; HPLC; CD Glycosides [35]
14-nor-β-patchoul-
1(5)-ene-2,4-dione
C14H18O2 Leaves/Stems TLC; NMR; IR; HR-ESI-MS Sesquiterpenoids [36]
2β-Methoxy-14-nor-β-patchoul-1(5)-
ene-4-one
C15H22O2 Leaves/Stems TLC; NMR; IR; HR-ESI-MS Sesquiterpenoids [36]
14-nor-β-patchoul-
1(5),2-diene-4-one
C14H18O Leaves/Stems TLC; NMR; IR; HR-ESI-MS Sesquiterpenoids Cytotoxic activities against NCIH1975 (IC50 = 49.9 µM) [36]
Cytotoxic activities against HePG-2 (IC50 = 56.0 µM)
14-nor-β-Patchoul-1(5)-ene-4-one C14H20O Leaves/Stems TLC; NMR; IR; HR-ESI-MS Sesquiterpenoids [36]
Pocahemiketals A C15H20O4 Aerial parts HR-ESI-MS; IR; NMR; X-ray; ECD Sesquiterpenoids [37]
Pocahemiketals B C14H20O3 Aerial parts HR-ESI-MS; IR; NMR; X-ray; ECD Sesquiterpenoids Vasorelaxant activity (EC50 = 16.32 µM) [37]
Patchouliguaiol A C15H24O2 Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids [38]
Patchouliguaiol B C15H26O2 Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids Neuroprotective effect (50µM) [38]
Patchouliguaiol C C15H24O2 Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids Vasorelaxant activity against PHE-induced contraction (EC50 = 5.4 µM) [38]
Antifungal activity against Candida albicans (MIC = 500 µM)
Patchouliguaiol D C15H22O Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids [38]
Patchouliguaiol E C15H20O Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids [38]
Patchouliguaiol F C15H24O2 Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids Vasorelaxant activity against PHE- induced contraction (EC50 = 1.6 µM) [38]
Vasorelaxant activity against KCl- induced contraction (EC50 = 24.2 µM)
Antifungal activity against Candida albicans (MIC = 300 µM)
Patchouliguaiol G C15H24O2 Aerial parts HR-ESI-MS; IR; NMR; ECD; X-ray Sesquiterpenoids Neuroprotective effect (50µM) [38]
7-epi-chabrolidione A C15H24O2 Aerial parts NMR Seco-guaianes Neuroprotective effect (50µM) [38]
1,7-di-epi-chabrolidione A C15H24O2 Aerial parts NMR Seco-guaianes Neuroprotective effect (50µM) [38]