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Table 4 Pharmacological activities of patchouli in anti-inflammation

From: Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review

Chemical name Animals/cells and Pathological model Type Efficient doses and administration route Results References
β-PAE LPS-stimulatedRAW264.7 macrophages In vitro 10, 20, 40 μmol/L TNF-α↓, IL-6↓, IL-1β↓, IL-10↑, iNOS↓, COX-2↓, NO↓, PGE2↓ [99]
Kun Ming (KM) mice; Xylene-induced ear edema, Acetic acid-induced vascular permeability, Carrageenan-induced paw edema In vivo 10, 20, 40 mg/kgoral administration MDA↓, MPO↓, TNF-α↓, IL-1β↓, PGE2↓, IL-6↓, NO↓, iNOS↓, COX-2↓, p65 (nuclear)↓ [100]
PAO KM mice; Xylene-induced ear edema, Acetic acid-induced vascular permeability, Carrageenan-induced paw edema In vivo 10, 20, 40 mg/kg oral administration TNF-α↓, IL-1β↓, IL-6↓, PGE2↓, NO↓, IL-4↑, IL-10↑, COX-2↓, iNOS↓, p-IKKβ and IκBα↓ [102]
LPS-stimulated RAW264.7 macrophages In vitro 10, 20, 40 μmol/L TNF-α↓, IL-12↓, IL-1β↓, MCP-1↓, PGE2↓, NO↓, iNOS↓, COX-2↓ [103]
PO Swiss mice; Zymosan-induced peritonitis In vivo 100, 200, 300 mg/kg oral administration Leukocyte recruitment↓, NO↓, leukocyte number↓ [104]
fMLP-induced neutrophils In vitro 1, 3, 10, 30, 60, 90 mg/ml Neutrophil migration↓
3, 10 mg/ml Phagocytic activity of neutrophils↑
  1. Note: Arrow up denotes activation; arrow down denotes suppression