Table 4 Pharmacological activities of patchouli in anti-inflammation
From: Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review
Chemical name | Animals/cells and Pathological model | Type | Efficient doses and administration route | Results | References |
|---|---|---|---|---|---|
β-PAE | LPS-stimulatedRAW264.7 macrophages | In vitro | 10, 20, 40 μmol/L | TNF-α↓, IL-6↓, IL-1β↓, IL-10↑, iNOS↓, COX-2↓, NO↓, PGE2↓ | [99] |
Kun Ming (KM) mice; Xylene-induced ear edema, Acetic acid-induced vascular permeability, Carrageenan-induced paw edema | In vivo | 10, 20, 40 mg/kgoral administration | MDA↓, MPO↓, TNF-α↓, IL-1β↓, PGE2↓, IL-6↓, NO↓, iNOS↓, COX-2↓, p65 (nuclear)↓ | [100] | |
PAO | KM mice; Xylene-induced ear edema, Acetic acid-induced vascular permeability, Carrageenan-induced paw edema | In vivo | 10, 20, 40 mg/kg oral administration | TNF-α↓, IL-1β↓, IL-6↓, PGE2↓, NO↓, IL-4↑, IL-10↑, COX-2↓, iNOS↓, p-IKKβ and IκBα↓ | [102] |
LPS-stimulated RAW264.7 macrophages | In vitro | 10, 20, 40 μmol/L | TNF-α↓, IL-12↓, IL-1β↓, MCP-1↓, PGE2↓, NO↓, iNOS↓, COX-2↓ | [103] | |
PO | Swiss mice; Zymosan-induced peritonitis | In vivo | 100, 200, 300 mg/kg oral administration | Leukocyte recruitment↓, NO↓, leukocyte number↓ | [104] |
fMLP-induced neutrophils | In vitro | 1, 3, 10, 30, 60, 90 mg/ml | Neutrophil migration↓ | ||
3, 10 mg/ml | Phagocytic activity of neutrophils↑ |