Fig. 4

Schematic diagram of the activation of the antioxidant signalling pathway by natural remedies against polyQ-induced SCA. PGC-1α peroxisome proliferator-activated receptor γ, NRF2 nuclear factor erythroid 2-related factor 2, ARE antioxidant response element, CYCS cytochrome c, NQO1 NAD(P)H Quinone Dehydrogenase 1, GCLC glutamate-cysteine ligase catalytic subunit, GSTP1 glutathione S-transferase pi 1, SOD2 superoxide dismutase 2, PolyQ polyglutamine, ROS reactive oxygen species