From: Therapeutic roles of natural remedies in combating hereditary ataxia: A systematic review
Disorder | Natural Remedies | Compounds | Model | Finding | Mode of Action | Reference |
---|---|---|---|---|---|---|
Medicinal plant | ||||||
 SCA3 | Rehmannia glutinosa | Catalpol | HEK-293 and SH-SY5Y cells | Promoted proteasome activity, suppressed polyQ aggregation, prevented cell death | UPS | [55] |
Pueraria lobate | Puerarin and daidzein | iPSCs | Promoted proteasome activity, suppressed polyQ aggregation, prevented cell death | [56] | ||
Gastrodia elata
| T1-11 and JMF-1907 | Mice | Promoted proteasome activity, prevented cell death, restored motor function | [57] | ||
Gardenia jasminoides | Genipin, geniposide and crocin | HEK-293 and SH-SY5Y cells | Promoted the expression of antioxidant genes, suppressed ROS level | NRF2 signalling pathway | [58] | |
Glycyrrhiza inflata | Licochalcone A and AMGZ | Promoted the expression of antioxidant genes, suppressed ROS level, suppressed polyQ aggregation | [59] | |||
Paeonia lactiflora | Paeoniflorin | Promoted expression of heat shock proteins, suppressed polyQ aggregation, restored motor function | N/A | [60] | ||
Brassica napus | Sinapine | Roundworm | Promoted expression of antioxidant genes, suppressed ROS level, restored motor function | N/A | [61] | |
SCA17 | Ginkgo biloba | N/A | SH-SY5Y cells and mice | Prevented calcium influx, prevented cell death | Calcium homeostasis | [62] |
Herbal formulation | ||||||
 SCA6 | Zhengan Xifeng Tang | N/A | Human | Restored motor function | N/A | |
 SCA17 | Shaoyao Gancao Tang | N/A | HEK-293 and SH-SY5Y cells | Promoted expression of antioxidant genes, prevented cell death, restored mitochondrial biogenesis, restored motor function | N/A | [65] |
Medicinal mushroom | ||||||
 FRDA | Hericium erinaceus | N/A | Fibroblast | Prevented antioxidant depletion, prevented cell death | N/A | [66] |