The mechanism of electroacupuncture for depression on basic research: a systematic review

Chinese Medicine

Table 1 Models of depression

Animal	Model type	Modeling time	Microbiology level	Sex	Strain	References
Rat	WKY	-	SPF	Male	Wistar	[20,21,22]
	CUMS	56 days 28 days	SPF SPF	Male Male	Sprague–Dawley Wistar Wistar	[23] [24] [25]
	CUS	70 days 49 days 28 days	SPF SPF SPF	Male Male Male	Sprague–Dawley Sprague–Dawley Sprague–Dawley	[26] [27] [28]
	CUMS	21 days	SPF CL	Male Male	Sprague–Dawley Wistar Sprague–Dawley	[29,30,31,32,33] [34,35,36,37] [38]
	CUMS	14 days	SPF	Male	Sprague–Dawley	[39]
	CRS	21 days 28 days	SPF SPF	Male Male	Sprague–Dawley Sprague–Dawley	[40] [41]
	CMS	28 days 77 days	SPF SPF	Male Male	Sprague–Dawley Sprague–Dawley	[42] [43]
	Pain-depression dyad	3 days	SPF	Male	Sprague–Dawley	[44]
	PSD	3 days	SPF	Male	Sprague–Dawley	[45]
	6-OHDA-lesioned	-	SPF	Male	Sprague–Dawley	[46]
	MS	21 days	SPF	Male	Wistar	[47]

WKY Wistar Kyoto, CUMS chronic unpredictable mild stress, CRS chronic restraint stress, 6-OHDA 6-hydroxydopamine, PSD poststroke depression, MS maternal separation, SPF specified pathogen free, CL clean animal

ISSN: 1749-8546