Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials

Liang, Zuanji; Chen, Xianwen; Shi, Junnan; Hu, Hao; Xue, Yan; Ung, Carolina Oi Lam

doi:10.1186/s13020-020-00422-x

Table 4 Evaluation of included trial studies using the CONSORT-CHM statement

From: Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials

Number	Authors, year	Title/abstract	Background	Objectives	Trial design	Participants	Interventions	Outcomes	Sample size	Randomization	Allocation	Implementation	Blinding	Statistical methods
1	Wu et al., 2020	△	◯	◯	△	◯	◯	◯	△	△	△	×	×	◯
2	Lyv et al., 2020	△	◯	◯	△	◯	◯	◯	△	△	△	×	×	◯
3	Yang et al., 2019	△	△	×	△	△	△	◯	△	△	△	×	×	◯
4	Yang et al., 2019	△	△	×	△	◯	◯	◯	△	△	×	×	×	◯
5	Li et al., 2018	△	△	◯	△	◯	△	◯	△	△	△	×	×	◯
6	Chen 2017	△	△	×	△	△	△	△	△	△	×	△	×	◯
7	Hu et al., 2017	△	×	△	△	◯	△	△	△	△	×	△	×	◯
8	Jiang et al., 2017	△	△	×	△	◯	△	△	△	△	×	△	×	◯
9	Yang et al., 2017	△	△	△	△	△	△	◯	△	△	△	×	×	◯
10	Jeong et al., 2017	◯	◯	◯	◯	△	△	◯	△	△	△	×	×	◯
11	Sun et al., 2017	△	×	×	△	◯	△	△	△	△	×	△	×	◯
12	Niu 2016	△	◯	△	△	◯	△	◯	△	△	×	×	×	△
13	Zhang et al., 2016	△	◯	◯	△	◯	◯	◯	△	△	△	△	×	◯
14	Zhang et al., 2016	△	×	×	△	◯	△	△	△	△	×	△	×	△
15	Qi et al., 2016	△	△	◯	△	◯	◯	◯	△	△	×	×	×	◯
16	Tan et al., 2016	△	△	×	△	◯	◯	◯	△	△	×	×	×	◯
17	Yu et al., 2016	△	△	×	◯	◯	△	△	△	△	×	△	×	◯
18	Yin et al., 2016	△	△	△	◯	◯	△	◯	△	△	×	×	△	◯
19	Zhu 2015	△	△	×	△	◯	◯	◯	△	△	△	×	×	◯
20	Li 2015	△	△	×	×	△	△	◯	△	△	×	×	×	◯
21	Chen et al., 2015	△	△	△	△	◯	◯	◯	△	△	△	×	△	◯
22	Yu et al.,2015	◯	◯	◯	△	◯	◯	◯	△	△	×	×	×	△
23	Li 2015	△	△	△	△	◯	△	◯	△	△	△	×	×	◯
24	Liu et al., 2014	△	◯	◯	◯	◯	◯	◯	△	△	×	×	×	◯
25	Liu et al., 2014	△	×	△	△	△	△	◯	△	△	×	×	×	◯
26	Li et al., 2014	◯	◯	◯	◯	◯	◯	◯	△	△	△	◯	△	◯
27	Zhu et al., 2014	△	△	◯	◯	◯	△	◯	△	△	×	△	×	◯
28	Wen et al., 2014	△	△	×	△	△	◯	◯	△	△	×	×	×	◯
29	Deng, 2013	△	△	◯	◯	◯	◯	◯	△	△	×	×	×	◯
30	Li et al., 2013	△	△	△	△	△	△	△	△	△	×	×	×	◯
31	Song et al., 2013	△	△	×	△	◯	◯	◯	△	△	×	×	×	◯
32	Li et al., 2013	△	△	◯	△	◯	△	△	△	△	×	△	×	◯
33	Wong et al., 2013	◯	◯	△	◯	◯	△	◯	△	△	△	◯	△	◯
34	Pan et al., 2013	◯	◯	◯	◯	◯	◯	◯	△	△	△	×	×	◯
35	Chen et al., 2012	△	△	×	△	◯	△	△	△	△	×	△	×	◯
36	Zhao et al., 2012	△	△	△	◯	△	△	△	△	◯	△	◯	△	△
37	Wang et al., 2012	△	△	×	△	◯	△	△	△	△	×	△	×	◯
38	Pei et al.,2012	△	◯	×	◯	◯	◯	◯	△	◯	◯	×	×	◯
39	Wu et al., 2012	△	×	×	△	△	△	△	△	△	×	×	×	◯
40	Tong et al., 2011	△	△	◯	△	◯	△	△	△	△	×	△	×	◯
41	Zhang et al., 2011	△	△	×	△	△	△	△	△	△	×	△	×	◯
42	Gu et al., 2011	△	△	◯	△	△	△	△	△	△	×	△	×	◯
43	Zhao et al., 2010	△	△	×	△	◯	△	◯	△	△	×	△	×	◯
44	Ding et al., 2010	△	△	◯	△	◯	△	△	△	△	×	△	×	◯
45	Pan et al., 2010	△	△	△	△	△	△	△	△	△	×	△	×	◯
46	Liu et al.,2008	△	△	△	△	◯	△	◯	△	◯	△	△	△	◯
47	Ji et al., 2008	◯	△	◯	◯	◯	△	△	△	◯	×	△	×	◯
48	Chen et al., 2008	△	△	◯	△	◯	△	◯	△	△	×	△	×	△
49	Lou et al., 2008	△	◯	△	◯	◯	△	△	△	◯	△	△	△	△
50	Li et al., 2007	△	◯	◯	△	△	△	◯	△	△	×	△	×	◯
51	Yang et al., 2007	△	×	×	△	△	△	△	△	△	×	△	×	◯
52	Gu et al., 2007	△	◯	△	◯	◯	△	△	△	◯	△	×	×	△
53	Chen et al., 2006	△	△	△	△	△	△	△	△	△	×	△	×	△

Number	Authors, year	Participant flow	Recruitment	Baseline data	Numbers analysed	Outcomes	Ancillary analysis	Harms	Limitations	Generalizability	Interpretation	Registration	Protocol	Funding
1	Wu et al., 2020	×	△	◯	◯	△	×	×	×	◯	◯	×	×	◯
2	Lyv et al., 2020	×	△	△	◯	△	×	×	×	◯	◯	×	×	◯
3	Yang et al., 2019	×	△	◯	◯	△	×	×	◯	△	△	×	×	◯
4	Yang et al., 2019	×	△	◯	◯	△	×	×	×	◯	◯	×	×	◯
5	Li et al., 2018	×	△	△	◯	△	×	◯	◯	△	△	×	×	◯
6	Chen 2017	×	△	◯	△	△	×	×	×	△	◯	×	×	◯
7	Hu et al., 2017	×	◯	◯	◯	△	×	◯	×	◯	◯	×	×	◯
8	Jiang et al., 2017	×	◯	◯	◯	△	×	◯	×	△	◯	×	×	◯
9	Yang et al., 2017	×	△	△	△	△	×	×	×	△	△	×	×	×
10	Jeong et al., 2017	◯	×	◯	◯	△	×	◯	△	△	△	◯	◯	×
11	Sun et al., 2017	×	◯	◯	△	△	×	×	×	△	◯	×	×	◯
12	Niu 2016	×	△	◯	◯	△	×	×	×	△	△	△	×	×
13	Zhang et al., 2016	×	△	×	◯	△	×	◯	×	△	△	×	×	◯
14	Zhang et al., 2016	×	×	◯	◯	△	×	×	×	△	△	×	×	◯
15	Qi et al., 2016	×	△	◯	◯	△	×	×	×	△	△	×	×	×
16	Tan et al., 2016	×	△	◯	◯	△	×	◯	×	△	△	×	×	×
17	Yu et al., 2016	×	△	◯	◯	△	×	×	×	△	△	×	×	◯
18	Yin et al., 2016	×	△	◯	△	△	×	×	×	△	△	×	×	◯
19	Zhu 2015	×	△	◯	◯	△	×	×	×	△	△	×	×	×
20	Li 2015	×	◯	◯	◯	△	×	◯	×	△	△	◯	×	×
21	Chen et al., 2015	×	△	◯	◯	△	×	◯	×	△	△	×	×	◯
22	Yu et al.,2015	×	△	◯	△	◯	×	◯	×	△	△	×	×	◯
23	Li 2015	×	△	△	◯	△	×	×	×	△	△	×	×	◯
24	Liu et al., 2014	×	△	×	◯	△	×	×	×	△	△	×	×	×
25	Liu et al., 2014	×	△	△	◯	△	×	△	×	△	△	×	×	◯
26	Li et al., 2014	×	△	◯	◯	△	×	◯	×	△	△	◯	×	×
27	Zhu et al., 2014	×	◯	△	◯	△	×	×	×	△	△	×	×	×
28	Wen et al., 2014	×	△	△	◯	△	×	◯	×	△	△	×	×	×
29	Deng, 2013	×	△	×	◯	△	×	×	×	△	△	×	×	×
30	Li et al., 2013	×	△	△	◯	△	×	◯	×	△	△	×	×	×
31	Song et al., 2013	×	△	◯	◯	△	×	×	×	△	△	×	×	×
32	Li et al., 2013	△	△	△	◯	△	×	◯	×	◯	△	×	×	×
33	Wong et al., 2013	◯	△	◯	◯	◯	×	◯	◯	△	△	◯	◯	×
34	Pan et al., 2013	◯	△	◯	◯	◯	△	◯	◯	△	△	◯	×	×
35	Chen et al., 2012	×	△	△	◯	△	×	×	×	◯	△	×	×	◯
36	Zhao et al., 2012	×	△	△	◯	△	△	◯	×	△	△	△	×	◯
37	Wang et al., 2012	×	△	△	◯	△	×	×	×	◯	◯	×	×	×
38	Pei et al.,2012	×	△	◯	◯	◯	×	◯	×	△	△	×	×	◯
39	Wu et al., 2012	◯	◯	△	△	△	×	◯	×	◯	△	×	×	◯
40	Tong et al., 2011	×	△	△	◯	△	×	◯	×	◯	△	×	×	×
41	Zhang et al., 2011	×	◯	◯	◯	△	×	◯	×	◯	△	×	×	×
42	Gu et al., 2011	×	◯	◯	◯	△	×	◯	×	◯	△	×	×	×
43	Zhao et al., 2010	×	△	×	◯	△	×	×	×	◯	◯	×	×	×
44	Ding et al., 2010	×	×	◯	◯	△	×	◯	×	◯	△	×	×	×
45	Pan et al., 2010	×	△	×	◯	△	×	◯	×	◯	△	×	×	×
46	Liu et al.,2008	×	◯	△	◯	△	×	×	×	◯	◯	×	×	×
47	Ji et al., 2008	×	△	◯	◯	△	×	△	×	◯	◯	×	×	◯
48	Chen et al., 2008	×	◯	◯	◯	△	×	×	×	◯	◯	×	×	×
49	Lou et al., 2008	×	◯	◯	◯	△	△	◯	×	△	△	△	×	×
50	Li et al., 2007	×	◯	×	◯	△	×	◯	×	△	◯	×	×	×
51	Yang et al., 2007	×	◯	△	◯	△	×	×	×	△	△	×	×	×
52	Gu et al., 2007	△	△	×	◯	△	×	◯	×	△	◯	◯	×	×
53	Chen et al., 2006	×	△	△	◯	△	△	×	×	△	△	△	×	×

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