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Table 5 Key articles in each cluster

From: The status of and trends in the pharmacology of berberine: a bibliometric review [1985–2018]

ClusterCoverageTGCSTitleFirst authorJournalYear
01434Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro studyLIU, LNaunyn-Schmiedebergs Archives of Pharmacology2010
11317Pharrnacokinetic properties, potential herb-drug interactions and acute toxicity of oral rhizoma coptidis alkaloidsMA, BLExpert Opinion on Drug Metabolism & Toxicology2013
21030Protoberberine alkaloids: physicochemical and nucleic acid binding properties., V10, P55, MBioactive Heterocycles IV Topics in Heterocyclic Chemistry2007
35226A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of turkish berberis speciesKUPELI, ELife Sciences2002
494Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assemblyYI, CMChemical Communications2017
5713Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisineSUZUKI, HBiological & Pharmaceutical Bulletin2010
6728Involvement of mitochondrial and b-raf/erk signaling pathways in berberine-induced apoptosis in human melanoma cellsBURGEIRO, AAnti-Cancer Drugs2011
7923Role of berberine in alzheimer’s diseaseCAI, ZYNeuropsychiatric Disease and Treatment2016
85121Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1 beta and inducible nitric oxide synthase in the rat model of alzheimer’s diseaseZHU, FQBMC Neuroscience2006
9580Berberine, a plant alkaloid with lipid- and glucose-lowering properties: from in vitro evidence to clinical studiesPIRILLO, AAtherosclerosis2015
10710Blockade of l-type calcium channel in myocardium and calcium-induced contractions of vascular smooth muscle by cpu 86017DAI, DZActa Pharmacologica Sinica2004
11354Coptidis rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active componentsYOKOZAWA, TJournal of Pharmacy and Pharmacology2004