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Table 5 Key articles in each cluster

From: The status of and trends in the pharmacology of berberine: a bibliometric review [1985–2018]

Cluster

Coverage

TGCS

Title

First author

Journal

Year

0

14

34

Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study

LIU, L

Naunyn-Schmiedebergs Archives of Pharmacology

2010

1

13

17

Pharrnacokinetic properties, potential herb-drug interactions and acute toxicity of oral rhizoma coptidis alkaloids

MA, BL

Expert Opinion on Drug Metabolism & Toxicology

2013

2

10

30

Protoberberine alkaloids: physicochemical and nucleic acid binding properties., V10, P55 https://doi.org/10.1007/7081_2007_071

MAITI, M

Bioactive Heterocycles IV Topics in Heterocyclic Chemistry

2007

3

5

226

A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of turkish berberis species

KUPELI, E

Life Sciences

2002

4

9

4

Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly

YI, CM

Chemical Communications

2017

5

7

13

Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine

SUZUKI, H

Biological & Pharmaceutical Bulletin

2010

6

7

28

Involvement of mitochondrial and b-raf/erk signaling pathways in berberine-induced apoptosis in human melanoma cells

BURGEIRO, A

Anti-Cancer Drugs

2011

7

9

23

Role of berberine in alzheimer’s disease

CAI, ZY

Neuropsychiatric Disease and Treatment

2016

8

5

121

Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1 beta and inducible nitric oxide synthase in the rat model of alzheimer’s disease

ZHU, FQ

BMC Neuroscience

2006

9

5

80

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: from in vitro evidence to clinical studies

PIRILLO, A

Atherosclerosis

2015

10

7

10

Blockade of l-type calcium channel in myocardium and calcium-induced contractions of vascular smooth muscle by cpu 86017

DAI, DZ

Acta Pharmacologica Sinica

2004

11

3

54

Coptidis rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components

YOKOZAWA, T

Journal of Pharmacy and Pharmacology

2004