Fig. 2

L. wallichii extracts alleviate inflammatory response and extracellular matrix (ECM) degradation in IL-1β-administrated primary mouse chondrocytes. a The relative mRNA levels of TNF-α, IL-6, IL-8, and IL-12 were detected in primary mouse chondrocytes treated by IL-1β or IL-1β + L. wallichii. b Western blotting was used to investigate the cellular level of p-p65, p65, p-κBα, and κBα protein. c The relative mRNA levels of MMP-13, Coll X, Aggrecan, and Coll II were detected in primary mouse chondrocytes treated by IL-1β or IL-1β + L. wallichii. d Western blotting was used to investigate the cellular level of MMP-13, Coll X, Aggrecan, and Coll II. Error bars ± SEM, *p < 0.05, **p < 0.01