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Fig. 1 | Chinese Medicine

Fig. 1

From: Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

Fig. 1

SKO showed cytotoxicity against MDA-MB-231 cells in a concentration- and time-dependent manner that independent of activation of RIP1/MLKL/RIP3 axis. a Chemical structure of SKO. b Cell viability of MDA-MB-231 cells treatment with different concentrations of SKO for different time. c The expression and quantitatively analysis of PARP and its cleaved product in cells treated with SKO for 12 h. d The expression of RIP1, RIP3, MLKL and their phosphorylated proteins in cells treated with SKO for 12 h. e Quantitatively analysis the relative expression of phosphorylated RIP1, RIP3, MLKL to total protein. Data was represented as means ± SEM. **p < 0.01 vs. untreated control group

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