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Fig. 4 | Chinese Medicine

Fig. 4

From: Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

Fig. 4

SKO facilitated ubiquitination of cIAP1 and cIAP2 in MDA-MB-231 cells. a Ubiquitination of proteins in cells treatment with or without of SKO at the indicated concentrations for 12 h. b Ubiquitination of proteins in cells treatment with SKO for the indicated time. c The expression of cIAP1, cIAP2 and RIP1 in cells treated with SKO for the indicated time. d Immunoprecipitation assay for ubiquitination of cIAP2 in cells treatment with or without of SKO at the indicated concentrations for 12 h. e Immunoprecipitation assay for ubiquitination of cIAP1 in cells treatment with or without of SKO at the indicated concentrations for 12 h

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