Table 4 Target distribution information of the top 20 enriched KEGG pathways
From: The important herbal pair for the treatment of COVID-19 and its possible mechanisms
Terms | Description | Genes |
|---|---|---|
hsa05152 | Tuberculosis | IL6, RELA, STAT1, IL10, MAPK1, CASP3, BAX, MAPK14, BCL2, CASP8, IFNG, MAPK3, IL1B, MAPK8, NOS2, IL1A |
hsa05145 | Toxoplasmosis | RELA, BCL2L1, STAT1, IL10, MAPK1, CASP3, CD40LG, MAPK14, BCL2, CASP8, IFNG, MAPK3, MAPK8, NOS2 |
hsa04620 | Toll-like receptor signaling pathway | IL6, RELA, CXCL8, STAT1, CXCL11, CXCL10, MAPK1, FOS, MAPK14, CASP8, MAPK3, IL1B, MAPK8 |
hsa04668 | TNF signaling pathway | ICAM1, IL6, CCL2, PTGS2, RELA, CXCL2, CXCL10, MAPK1, FOS, CASP3, MAPK14, CASP8, MAPK3, IL1B, MAPK8 |
hsa04660 | T cell receptor signaling pathway | IL4, MAPK1, FOS, CD40LG, MAPK14, RELA, MAPK3, IFNG, IL10, IL2 |
hsa05132 | Salmonella infection | IL6, RELA, CXCL2, CXCL8, MAPK1, FOS, MAPK14, IFNG, MAPK3, IL1B, MAPK8, NOS2, IL1A |
hsa05133 | Pertussis | IL6, RELA, CXCL8, IL10, MAPK1, FOS, CASP3, MAPK14, MAPK3, IRF1, IL1B, MAPK8, NOS2, IL1A |
hsa05200 | Pathways in cancer | PRKCA, EGFR, IL6, PTGS2, RELA, PPARG, CXCL8, RB1, BCL2L1, STAT1, PRKCB, MAPK1, FOS, CASP3, BAX, BCL2, CASP8, MAPK3, MAPK8, NOS2 |
hsa04380 | Osteoclast differentiation | MAPK1, FOS, MAPK14, RELA, MAPK3, PPARG, IFNG, IL1B, MAPK8, STAT1, IL1A |
hsa04621 | NOD-like receptor signaling pathway | MAPK1, IL6, CCL2, MAPK14, RELA, MAPK3, CASP8, CXCL2, CXCL8, IL1B, MAPK8 |
hsa04010 | MAPK signaling pathway | PRKCA, EGFR, FOS, MAPK1, CASP3, MAPK14, RELA, MAPK3, HSPB1, IL1B, |
hsa05144 | Malaria | ICAM1, IL6, CCL2, CD40LG, IFNG, CXCL8, IL1B, IL10 |
hsa05140 | Leishmaniasis | IL4, PTGS2, RELA, STAT1, IL10, FOS, MAPK1, MAPK14, IFNG, MAPK3, IL1B, NOS2, IL1A |
hsa05164 | Influenza A | PRKCA, ICAM1, IL6, CCL2, RELA, CXCL8, STAT1, PRKCB, CXCL10, MAPK1, MAPK14, IFNG, MAPK3, IL1B, MAPK8, IL1A |
hsa05321 | Inflammatory bowel disease (IBD) | IL4, IL6, RELA, IFNG, IL1B, STAT1, IL10, IL1A, IL2 |
hsa04066 | HIF-1 signaling pathway | PRKCA, EGFR, MAPK1, IL6, RELA, HMOX1, BCL2, MAPK3, SERPINE1, IFNG, NOS3, NOS2, PRKCB |
hsa05161 | Hepatitis B | PRKCA, FOS, MAPK1, CASP3, IL6, BCL2, RELA, BAX, CASP8, MAPK3, CXCL8, MAPK8, RB1, STAT1, PRKCB |
hsa04060 | Cytokine-cytokine receptor interaction | IL4, IL6, CCL2, CXCL2, CXCL8, CXCL11, IL10, CXCL10, CD40LG, IFNG, IL1B, IL1A, IL2 |
hsa05142 | Chagas disease (American trypanosomiasis) | IL6, CCL2, RELA, CXCL8, IL10, MAPK1, FOS, MAPK14, CASP8, IFNG, SERPINE1, MAPK3, IL1B, MAPK8, NOS2, IL2 |
hsa05146 | Amoebiasis | PRKCA, CASP3, IL6, RELA, IFNG, CXCL8, HSPB1, IL1B, NOS2, IL10, PRKCB |