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Table 3 MICs of S. officinalis used alone and in combination with four antibiotics

From: In vitro anti‐bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection

Antibiotics

Strains

MIC (μg/ml)

FICI a

Interaction b

S.officinalis

Antibiotic

S. officinalis + Antibiotic

CLR

SS1

160

0.016

160 + 0.001/10 + 0.016

1.0625

Additive

LQ2#

320

6.4

160 + 1.6/10 + 6.4

0.75/1.031

Additive

LEF

SS1

160

1.6

160 + 0.05

1.0625

Additive

700,392

160

0.8

160 + 0.05/10 + 0.8

1.0625

Additive

MTZ

SS1

160

1.6

80 + 0.8

1.0

Additive

700,392

160

1.6

160 + 0.1/10 + 1.6

1.0625

Additive

LQ2#

320

6.4

160 + 3.2

1.0

additive

AMO

SS1

160

0.4

160 + 0.025/10 + 0.4

1.0625

Additive

700,392

160

0.1

160 + 0.006

1.0625

Additive

LQ2#

320

3.2

160 + 1.6

1.0

Additive

  1. aFractional inhibitory concentration index, FICI = (MIC of S. officinalis in combination/MIC of S. officinalis alone + MIC of Antibiotic in combination/MIC of Antibiotic alone). bInteraction between S. officinalis and every antibiotic was defined according to the following principle: FICI ≤ 0.5, synergistic; 0.5 < FICI ≤ 4, additive; FICI > 4, antagonistic