Fig. 3

Effect of SF on joint bone destruction and serum bovine CII-specific IgG level in CIA mice. a Representative image of H&E and Safranin O staining in ankle joints (Scale bars, 500 and 100 μm). b Evaluation of joint pathology and cartilage of mice in each group (n = 5). c Levels of total anti-bovine collagen II IgG, IgG2a, and IgG2b in mice sera (n = 5). One-way ANOVA and post hoc Dunnett’s test were performed between multiple groups. ^####p < 0.0001, compared with Normal group; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, compared with CIA vehicle group