Table 1 Summary of previously reported functions of compounds hits
Compound | Formula | Herbal origins | Suggested function |
|---|---|---|---|
Baicalin | GQD | Scutellaria Baicalensis | Cardioprotection [45], enhancing glucose uptake and insulin sensitivity [46], anti-inflammation, anti-bacterial infection [47], anti-tumor [48], anti-oxidative stress, anti-allergy [49] |
Daidzin | GQD | Radix Puerariae | Anti-tumor [50], anti-inflammation [51], anti-oxidative stress [52] |
3ʹ-Methoxypuerarin | GQD | Radix Puerariae | Hepatoprotective [53] |
Oroxindin | GQD | Scutellaria Baicalensis | Anti-inflammation, anti-tumor, anti-oxidative stress [54], anti-bacterial infection, anti-proliferation [55] |
Glycyrrhizic acid | GQD | Glycyrrhiza Uralensis Fisch | Anti-viral infection [56], anti-inflammation [57], hepatoprotective [58], anti-cancer, anti‑ulcer, anti‑anaphylaxis [59] |
Puerarin | GQD | Radix Puerariae | Vasodilation, cardio-protective [60], neuroprotection, anti-oxidation, anti-inflammation [61], anti-cancer [62], alleviating pain, promoting bone formation, inhibiting alcohol uptake [63], attenuating insulin resistance [60] |
Oroxyloside | GQD | Scutellaria Baicalensis | Inhibiting angiogenesis [64], anti-cancer [65], hepatoprotective [66], anti-inflammation [29] |
Esculin | PD | Cortex Fraxini | Hepatoprotective [67], anti-bacterial infection, anti-inflammation [68], anti‑allergy, skin protection [69], anti-thrombosis, anti-oxidative stress [70] |
Fraxin | PD | Cortex Fraxini | Hepatoprotective, anti-oxidative stress [71], anti-inflammation [72] |
Phellodendrine | PD | Phellodendron Chinense Schneid | Anti-oxidative stress, anti-inflammation, reducing blood pressure [73] |
Palmatine | PD | Coptis Chinensis Franch | Anti-cancer, anti-oxidation, anti-inflammation, neuroprotection, anti-bacterial and virus infection, regulating blood lipids [74] |
Berberine | PD | Coptis Chinensis Franch | Anti-microbial infection, anti-diabetis, anti-cancer, lipid-lowering, anti-diarrhea, antitrachoma, anti-oxidation, anti-inflammation, antiviral infection [75,76,77] |
Chlorogenic acid | PD | Phellodendron Chinense Schneid | Anti-oxidative stress, anti-microbial infection, hepatoprotective, cardioprotective, anti-inflammation, antipyretxia, neuroprotection, anti-obesity, anti-hypertension, anti-oxidative stress, neuronal stimulation [78,79,80,81] |