Fig. 3From: Cerebralcare GranuleĀ® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functionsOFT and CG alleviated neuronal damage and improves synaptic function in mice brain. aāc OFT was conducted on APP/PS1 mice (nā=ā10). a The representative record of motion trajectories showed the locomotor path of all groups of mice. b Runnning time. c Total squares acrossed. d HE-stained images of hippocampal CA1 and DG area in APP/PS1. Scale barā=ā200Ā Ī¼m. In APP/PS1 mice, the damaged neurons were deeply stained, and the neuron bodies were atrophied and appeared triangular. Cells are arranged indisorder with a slightly changed cell polarity. By contrast, treatment with CG, Mm, and CGā+āMm significantly inhibited the histopathological damage. e Golgi staining of the hippocampus, Scale barā=ā10Ā Ī¼m. ^ Pā<ā0.05, ^^ Pā<ā0.01, ^^^ Pā<ā0.01 vs. WT group; * Pā<ā0.05, ** Pā<ā0.01, *** Pā<ā0.01 vs. Tg group; # Pā<ā0.05, ## Pā<ā0.001, ### Pā<ā0.001, vs. Mm group, & Pā<ā0.05, && Pā<ā0.001, &&& Pā<ā0.001, vs. CG group (nā=ā10)Back to article page