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Fig. 3 | Chinese Medicine

Fig. 3

From: Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions

Fig. 3

OFT and CG alleviated neuronal damage and improves synaptic function in mice brain. ac OFT was conducted on APP/PS1 mice (n = 10). a The representative record of motion trajectories showed the locomotor path of all groups of mice. b Runnning time. c Total squares acrossed. d HE-stained images of hippocampal CA1 and DG area in APP/PS1. Scale bar = 200 μm. In APP/PS1 mice, the damaged neurons were deeply stained, and the neuron bodies were atrophied and appeared triangular. Cells are arranged indisorder with a slightly changed cell polarity. By contrast, treatment with CG, Mm, and CG + Mm significantly inhibited the histopathological damage. e Golgi staining of the hippocampus, Scale bar = 10 μm. ^ P < 0.05, ^^ P < 0.01, ^^^ P < 0.01 vs. WT group; * P < 0.05, ** P < 0.01, *** P < 0.01 vs. Tg group; # P < 0.05, ## P < 0.001, ### P < 0.001, vs. Mm group, & P < 0.05, && P < 0.001, &&& P < 0.001, vs. CG group (n = 10)

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